Efficiency Of Combination Of Scar Subcision With Platelet Rich Plasma, Polydioxanone Mono Threads Or Fractional Carbon Dioxide Laser In The Treatment Of Severe Atrophic Acne Scars: A Randomized Controlled Study
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 48
- 主要终点
- Management of severe atrophic acne scars
研究概览
简要总结
Many methods utilize for acne scar treatment including laser, cosmetic filler, microneedling, local tumescent, Subcision and chemical peels. These procedures can be used individually or as a combination therapy.
Combining procedures give better results. In our study we will try in the period from March 2024 to March 2026, to assess the efficacy of combination of scar subcision with platelet rich plasma, Polydioxanone mono threads or fractional Carbon dioxide laser in the treatment of severe atrophic acne scars with 1:1:1 ratios and to compare between these modalities regarding safety and efficacy.
详细描述
This is a prospective controlled trial that will be conducted at Dermatology, venereology, and andrology Department, Al-Azhar university hospital, Assiut, in the period from March 2024 to March 2026, to assess the efficacy of combination of scar subcision with platelet rich plasma , polydioxanone mono threads or fractional carbon dioxide laser in the treatment of severe atrophic acne scars with 1:1:1 ratios and to compare between these modalities regarding safety and efficacy
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with severe atrophic acne scars (as per Goodman and Baron's acne qualitative scar grading scale)
排除标准
- •Patients with active acne lesions.
- •Patients having a keloid formation tendency.
- •Patients with a history of bleeding disorder or severe anemia.
- •Pregnant or lactating women.
- •Patients received any treatment for scars in the last 6 months.
- •Patients using drugs causing photosensitivity or systemic retinoids in the previous 6 months (for laser group).
研究组 & 干预措施
Subcision plus platelet rich plasma
3 sessions of scar subcision with platelet rich plasma injection at the same session with one month interval
干预措施: Scar subcision (Procedure)
Subcision plus platelet rich plasma
3 sessions of scar subcision with platelet rich plasma injection at the same session with one month interval
干预措施: Platelet rich plasma injection (Procedure)
Subcision plus Polydioxanone mono threads
3 sessions of scar subcision followed by the insertion of Polydioxanone mono threads after the last session
干预措施: Scar subcision (Procedure)
Subcision plus Polydioxanone mono threads
3 sessions of scar subcision followed by the insertion of Polydioxanone mono threads after the last session
干预措施: Polydioxanone mono threads insertion (Procedure)
Subcision plus fractional carbon dioxide laser
3 sessions of scar subcision with Fractional carbon dioxide laser at the same session with one month interval
干预措施: Fractional carbon dioxide laser (Device)
Subcision plus fractional carbon dioxide laser
3 sessions of scar subcision with Fractional carbon dioxide laser at the same session with one month interval
干预措施: Scar subcision (Procedure)
结局指标
主要结局
Management of severe atrophic acne scars
时间窗: 2 years
to assess the efficacy of the combination of subcision with Platelet rich plasma, Polydioxanone mono threads or fractional carbon dioxide laser in the treatment of severe atrophic acne scars (As per Goodman and Baron's acne qualitative scar grading scale)
次要结局
- Comparing the 3 lines(2 years)
研究者
Ahmed Omar Abdulrahman Hassan
Principal investigator
Al-Azhar University