Role of Aschistosoma Haematobiumspecific microRNAas Atumor Marker for Early Diagnosis and Prognosis of Bilharzial Bladder Cancer in Eygpt
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 主要终点
- use micro RNAas adiagnostic test for early diagnosis of shistosomal bladder cancer
研究概览
简要总结
miRNAs have been detected in different bodily fluids, which suggests significant potential, such as their use as biomarkers in diagnostics and prognostics. Sha-mir-71a was abundantly found in the urine of patients with bladder cancer as compared to benign bladder cystitis associated with schistosomiasis . Additionally, this miRNA was more highly detected in urine samples from patients with bilharzial bladder cancer than bladder cancer not associated with bilharziasis (schistosomiasis), suggesting its specificity in the identification of bladder cancer associated with infection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •urinary symptoms (hematuria, urinary retention, dysuria... etc.), who were planned to undergo cystoscopy for suspicion of bladder cancer (BC) or benign bilharzial cystitis (Bil), will be selected.
排除标准
- •: In bladder cancer group Patients who have received chemotherapy, or with previously diagnosed other malignancy within the past 5 years.
结局指标
主要结局
use micro RNAas adiagnostic test for early diagnosis of shistosomal bladder cancer
时间窗: one year
Sha-mir-71a could be a biomarker with diagnostic and prognostic value
次要结局
未报告次要终点
研究者
Esraa Omar Ali
assistant lecturar at parasitology department
Sohag University