Effects of a Liquid Meal and Gut Hormones (GIP and GLP-2) on Bone Remodeling in Participants With Hypoparathyroidism (KS-4-HypoPT).
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 1
- 主要终点
- Serum concentration of C-terminal telopeptide (CTX)
研究概览
简要总结
Hypoparathyroidism (hypoPT) is characterized by low levels of PTH.
In this study we will test the effects of a liquid meal on the bone remodeling in participants with hypoparathyroidism. Furthermore, we will test the effects of the gut hormones GIP and GLP-2.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 76 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18 and 76
- •Hypoparathyroidism
排除标准
- •Disease in the gastrointestinal tract
- •Antiosteoporotic drug
- •Long term steroid treatment (within the last 12 months)
- •Pregnancy
研究组 & 干预措施
Placebo (saline)
Placebo (saline)
干预措施: Placebo (saline) (Other)
Liquid meal (Nutridrink)
Liquid meal (Nutridrink)
干预措施: Liquid meal (Nutridrink) (Other)
GIP
Glucose-dependent insulinotropic polypeptide
干预措施: GIP (Other)
GLP-2
Glucagon-like peptide-2
干预措施: GLP-2 (Other)
结局指标
主要结局
Serum concentration of C-terminal telopeptide (CTX)
时间窗: -10 to 240 minutes
Marker of bone resorption, measured in serum
N-terminal propeptide of type 1 procollagen (P1NP)
时间窗: -10 to 240 minutes
Marker of bone formation, concentration measured in serum
次要结局
- Glucose-dependent insulinotropic polypeptide (GIP)(-10 to 240 minutes)
- Glucagon-like peptide-2 (GLP-2)(-10 to 240 minutes)
- PTH(-10 to 240 minutes)
- Glucagon-like peptide-1 (GLP-1)(-10 to 240 minutes)
- Glucose(-10 to 240 minutes)
- Insulin(-10 to 240 minutes)
- C-peptide(-10 to 240 minutes)
研究者
Kirsa Skov-Jeppesen
principal investigator. Cand.pharm., ph.d. student
University of Copenhagen