Effectiveness of Integrated Livelihood and Nutrition Interventions to Improve Maternal and Child Nutrition and Health in Rural Uganda: A Birth Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 5,044
- 试验地点
- 1
- 主要终点
- Percentage of infants with low birth weight
研究概览
简要总结
The UBC was a USAID-funded longitudinal prospective cohort study of pregnant women (n= 5030) aged 15-49 years from rural North and South-Western regions of Uganda, conducted between 2014 and 2016. The aim of the UBC study was to observationally follow pregnant women and their newborns until 2 years of age and compare changes over time in communities that were part of an ongoing USAID project called the Community Connector (CC) compared to those communities that were not included in the Community Connector project.
详细描述
This study aimed to assess the role of livelihoods, agriculture and nutrition in improving maternal and child nutrition and health in rural Uganda in communities that were a part of an ongoing program that was un-related to the study. The overall aim of this study was to understand the effect of participating in an ongoing program that provided support on nutrition, agriculture, water, hygiene and sanitation and the change over time in the nutritional status of mothers and children under two years of age. The specific objectives of this observational study were as follows:
- To compare health and nutrition status of pregnant women in communities participating in the Community Connector project to those that were not participating in the program
- To assess the aflatoxin levels in pregnancy and test its association with birth outcomes and early life growth as measured by weight and length
- To assess environmental enteropathy in pregnancy and test its association with birth outcomes and early life growth
- To assess access to coverage and adherence to information/messages and engagement in Community Connector project's activities
- To determine heterogeneity in program exposure and variability in household and agro-ecological characteristics and its relationship with maternal and infant health and nutrition status
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Years 至 49 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Percentage of infants with low birth weight
时间窗: Birth
Percentage of infants with birth weight less than 2500 grams
Percent of infants who were underweight
时间窗: 0-2 years old
Percent of infants with a weight-for-age less than -2 standard deviations
Infants' weight at birth (kg)
时间窗: Birth
Birth weight in kilograms using a seca scale, calculated as the mean of three repeated measurements on each infant
Percentage of preterm births
时间窗: Birth
Percentage of infants born with a gestational age less than 259 days
Percentage of infants who were small-for-gestational-age
时间窗: Birth
Percentage of infants at birth whose weight centiles were below the 10th percentile for their age and sex
Percent of infants who were stunted
时间窗: 0-2 years old
Percent of infants with a height-for-age less than -2 standard deviations
Percent of infants who were wasted
时间窗: 0-2 years old
Percent of infants with a weight-for-height less than -2 standard deviations
Head circumference measurement (cm)
时间窗: 0-2 years old
Infant's head circumference measured in centimeters
次要结局
- Percent of mothers that were anemic (hemoglobin levels <11 g/dL)(through study completion, every 3 months)
- Percent of infants that were anemic (hemoglobin levels <11 g/dL)(0-2 years old)
- Concentration of ferritin (ug/L) in mothers and infants as a biomarker for iron status(6 months for infants, mothers at birth)
- Concentration of soluble transferrin receptor (mg/L) in mothers and infants as a biomarker for iron status(6 months for infants, mothers at birth)
- Concentration of retinol binding protein (umol/L) in mothers and infants as a biomarker for vitamin A status(6 months for infants, mothers at birth)
研究者
Patrick Webb
Program Director
Tufts University