Retinal Vascular Reactivity in Response to Isoxic Hypercapnia in Subjects With Newly Diagnosed Glaucoma
试验速览
- 阶段
- 不适用
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- blood flow
研究概览
简要总结
The purpose of this study is to assess retinal blood flow and vascular reactivity in patients with newly diagnosed primary open angle glaucoma pre- and post-primary Selective Laser Trabeculoplasty(SLT). Canon Laser Blood Flowmeter will be used for the assessment of retinal blood flow.
详细描述
We previously found that vascular reactivity improved after short term treatment with dorzolamide drops. It is not clear whether this improvement was a direct effect of the medication or secondary effect of the decrease in IOP. We would like to see the change of vascular reactivity before and after SLT, which will decrease the intraocular pressure without pharmacologic effect.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 40-75 years (Male or Female)
- •Best corrected visual acuity of at least 20/40
- •No previous treatment for glaucoma
- •Ametropia less than ±6.0 DS and ±2.5 DC)
- •No cardiovascular/respiratory disorders
排除标准
- •Past history of diabetes and cerebrovascular accident
- •Vascular occlusive disease affecting the ocular circulation such as: diabetic retinopathy, retinal vein occlusion and retinal artery occlusion
- •Previous intraocular surgery
- •Ocular media opacities limiting the use of the imaging tests
结局指标
主要结局
blood flow
时间窗: before and two-week after SLT
The Canon Laser Blood Flowmetry will be used to assess the retinal blood flow.
次要结局
- Intraocuclar pressure(before and two-week after SLT)