NL-OMON48436已完成不适用
Quantitative MRI of extra-ocular muscles in myasthenia gravis - Quantitative MRI of extra-ocular muscles in myasthenia gravis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 89
研究概览
简要总结
Trial is onging in other countries
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Recently diagnosed MG patients
- •- Definitive diagnosis of MG defined as the presence of serum autoantibodies
- •(anti-acetylcholine receptor [AChR], anti-muscle specific tyrosine kinase
- •- Start of symptoms was less than a year ago
- •- No corticosteroid treatment received in the past year
- •- No TSH-receptor auto-antibodies, no laboratory signs of thyroid dysfunction
- •(T4, TSH), Chronic MG patients
- •- Definitive diagnosis of MG, defined as described above
- •- Persisting symptoms of diplopia
- •- Start of symptoms was more than a year ago
- •- No TSH-receptor auto-antibodies, no laboratory signs of thyroid dysfunction
- •(T4, TSH), Seronegative MG patients
- •- Clinical diagnosis of MG with asymmetric, fluctuating and fatigable muscle
- •weakness and at least one abnormal neurophysiological test, indicative of
- •neuromuscular dysfunction (repetitive nerve stimulation or single fiber EMG)
- •- No serum autoantibodies (anti-acetylcholine receptor [AChR], anti-muscle
- •specific tyrosine kinase [MuSK])
- •- No TSH-receptor auto-antibodies, no laboratory signs of thyroid dysfunction
- •Healthy controls
- •- No symptoms of diplopia
- •- No ophthalmopathy
- •- No prior systemic treatment with corticosteroids, Patient controls: Graves*
- •orbitopathy
- •- Definitive diagnosis of Graves* orbitopathy, Patient controls: Other
- •neuromuscular disease
- •- Definitive diagnosis of a neuromuscular disease other than Myasthenia gravis
排除标准
- •- Subjects who are not legally capable
- •- Subjects under the age of 18
- •- Contraindications to MRI scanning, including:
- •o Claustrophobia
- •o Pregnancy
- •o Pacemakers and defibrillators
- •o Nerve stimulators
- •o Intracranial clips
- •o Metallic fragments
- •o Cochlear implants
- •o Ferromagnetic implants
- •o Hydrocephalus pump
- •o Permanent make-up
- •o Tattoos above the shoulders
- •o Piercings (unless they can be removed)
- •o Subjects who cannot keep their head still (eg. Tremor, Parkinson*s disease)
- •o Severe physical restriction (completely wheelchair dependent)
- •* In the case of uncertainty about the MRI-contraindications, the MR-safety
- •commission of the radiology department will decide whether this subject can be
- •included in the study or not.
研究者
相似试验
已完成
不适用
Quantitative MR Imaging of skeletal muscle in Duchenne and Becker muscular dystrophy10028302Duchenne muscular dystrophyNL-OMON47455Radiologie74
招募中
不适用
MRI of eye muscles in myasthenia gravisNL-OMON23441eiden University Medical Center130
已完成
不适用
Occipital nerve stimulation in patients with medically intractable chronic cluster headache: A PET study10019231cluster headacheNL-OMON39533eids Universitair Medisch Centrum24
已完成
不适用
A Maastricht Contrast-Induiced-Nehropathy Guideline study (AMACING): prevention guidelines - appropriate and cost effective?acute kidney injury (AKI)acute renal insufficiency10029149NL-OMON44751Medisch Universitair Ziekenhuis Maastricht660
已完成
不适用
on-invasive assessment of skeletal muscle involvement in Duchenne muscular dystrophyDuchenne Muscular Dystrophy10028302NL-OMON39843eids Universitair Medisch Centrum38