TCTR20191219003进行中（未招募）1 期
Ineffectiveness of 14-day Vonoprazan-based dual therapy and Vonoprazan-based triple therapy for Helicobacter pylori Eradication in area of high Clarithromycin resistance: A prospective randomized study
/A0 个研究点目标入组 100 人开始时间: 2019年12月19日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 75 Years（—）
- 性别
- All
入选标准
- •Thai patients with the age between 18 and 75 years
- •Detecting for H.pylori infection with positive urease test and/or pathological findings of H.pylori and/or positive
排除标准
- •Any cases with upper gastrointestinal bleeding
- •Being treated with medications affecting the research outcome, for example, by using antibiotics including amoxicillin, clarithromycin, metronidazole or fluoroquinolone within 1 month before the enrollment.
- •Contraindicated for gastric biopsy such as coagulopathy.
- •Any history of drug allergy for amoxicillin, clarithromycin or vonoprazan.
- •Receiving proton pump inhibitor within 4 weeks or receiving any antibiotics or bismuth within 2 weeks.
- •Being pregnant or raising children with lactation.
- •Having history of H.pylori eradication treatment.
- •Having severe underlying disease including end-stage renal disease requiring hemodialysis or peritoneal dialysis (GFR < 15), cirrhosis with Child-Pugh classification grade C, immunocompromised host with AIDS, malignancy and/or bed ridden cerebrovascular disease.
- •Any cases who receiving anticoagulant.
- •Having previous gastric surgery.
- •Unwilling to participate into research.
- •Having history of taking previous medications which interacted with the research treatment.
- •Having underlying heart disease including congenital long QT syndrome.
研究者
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