The Effect of Omega-3 Supplementation on Muscle Functioning, Inflammation and Muscle Signaling in Elderly
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Isometric muscle strength
研究概览
简要总结
Elderly are supplemented with either Omega-3 (3 x 1.1g per day) or placebo (corn oil) during 14 weeks. The last 12 weeks, supplementation is combined with resistance exercise training (3x per week) focusing on upper leg strength. In the present project, the investigators study whether differences in muscle strength and/or muscle mass between conditions can be explained by omega-3-induced effects on systemic or muscle inflammatory signaling, or differences in muscle molecular signaling.
详细描述
Elderly are supplemented with either Omega-3 (3 x 1.1g per day) or placebo (corn oil) during 14 weeks. The last 12 weeks, supplementation is combined with resistance exercise training (3x per week) focusing on upper leg strength. In the present project, the investigators study whether differences in muscle strength and/or muscle mass between conditions can be explained by omega-3-induced effects on systemic or muscle inflammatory signaling, or differences in muscle molecular signaling.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
Subjects are a priori randomized to one of both conditions. Both groups undergo an identical intervention, but receive different supplements (although appearance-matched). The investigators do not know in which condition the subjects are randomized. One researcher, who is not involved in the intervention/data collection/data analyses, holds the code.
入排标准
- 年龄范围
- 65 Years 至 100 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged >= 65 years
排除标准
- •BMI < 20; BMI > 35
- •regular NSAID intake in the last 3 months
- •omega-3 supplementation in the last year
- •regular resistance exercise in the last year
- •cancer, liver and renal disease, unstable cardiovascular disease, musculoskeletal disease
- •cognitive limitations that might interfere with the (adherence to) the intervention or with the testing of outcome parameters
- •unstable body weight
研究组 & 干预措施
Omega-3
Elderly supplemented with omega-3.
干预措施: Omega-3 polyunsaturated fatty acid supplementation (Dietary Supplement)
Omega-3
Elderly supplemented with omega-3.
干预措施: Resistance exercise (Other)
Placebo
Elderly supplemented with corn oil.
干预措施: Resistance exercise (Other)
Placebo
Elderly supplemented with corn oil.
干预措施: Placebo - appearance-matched oil supplementation (Dietary Supplement)
结局指标
主要结局
Isometric muscle strength
时间窗: Change in muscle strength between prior to and following the study intervention of 14 weeks (Jan - May 2019)
Isometric muscle strength as assessed with Biodex Device in Nm
Systemic inflammatory signaling
时间窗: Change in inflammatory signaling between prior to and following the study intervention of 14 weeks (Jan - May 2019)
Systemic (blood) markers of inflammation: hs-CRP (mg/L), IL-6 (pg/mL), TNFa (pg/mL)
Muscle strength
时间窗: Change in muscle strength between prior to and following the study intervention of 14 weeks (Jan - May 2019)
One Repetition Maximum on the leg press fitness device in kg
次要结局
- Muscle quality(Change in muscle quality between prior to and following the study intervention of 14 weeks (Jan - May 2019))
- Muscle molecular signaling (Protein levels of anabolic/catabolic signaling and skeletal muscle stress)(Change in muscle molecular signaling between prior to and following the study intervention of 14 weeks (Jan - May 2019))