Serratus Anterior Plane Block Versus Erector Spinae Plane Block With Dexmedetomidine Added to Bupivacaine for Ultrasound-Guided Pain Management After Mastectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Total dose of pethidine consumption
研究概览
简要总结
This study aimed to compare the serratus plane block versus the erector spinae plane block with dexmedetomidine added to bupivacaine for acute pain management after breast surgeries.
详细描述
Approximately 40-60% of breast surgery patients endure severe acute postoperative pain, with over 10% of patients experiencing severe pain for six to twelve months (post-mastectomy pain syndrome).
Dexmedetomidine has analgesic properties, which could be related to the stimulation of α2 adrenoceptors, inhibition of nerve conduction through C and Aδ fibers, and the local release of encephalin.
Serratus plane block (SPB) is an effective approach for breast surgery analgesia due to its simplicity of delivery, minimal risk of adverse effects, and ability to provide significant pain relief.
The erector spinae plane block (ESPB) is one of the emerging regional techniques for managing postoperative pain. ESPB can be given unilaterally during modified radical mastectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women aged >20 years.
- •Patient's approval.
- •American Society of Anesthesiologists (ASA) physical status I-II.
- •Patients underwent breast surgeries.
排除标准
- •Known allergy to local anesthetics, opioids, or dexmedetomidine medications.
- •Advanced heart block, ventricular dysfunction.
- •Skin infection at the site of injection.
- •Pre-existing chronic pain.
- •Coagulopathies, significant liver or renal insufficiency.
研究组 & 干预措施
Serratus anterior plane block group
Patients received serratus anterior plane block on the operated side with bupivacaine 0.25% plus 0.5 µg/kg dexmedetomidine in 30 ml.
干预措施: Bupivacaine + Dexmedetomidine (Drug)
Erector spinae plane block group
Patients received erector spinae plane block at T5 on the operated side and will receive bupivacaine 0.25% plus 0.5 µg/kg dexmedetomidine in 30 ml.
干预措施: Bupivacaine + Dexmedetomidine (Drug)
结局指标
主要结局
Total dose of pethidine consumption
时间窗: 24 hours postoperatively
Patients get 1 g paracetamol IV like clockwork. Salvage absence of pain as bolus IV pethidine at 0.5 mg/kg was managed if NRS \> 3
次要结局
- Intraoperative fentanyl consumption(Intraoperatively)
- Heart rate(Every 15 minutes until the end of the surgery (Up to 2 hours))
- Mean arterial pressure(Every 15 minutes until the end of the surgery (Up to 2 hours))
- Degree of pain(24 hours postoperatively)
- Incidence of complications(24 hours postoperatively)
研究者
Hend Saad Rizk Farhat
Resident of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Kafrelshiekh University, Kafrelshiekh, Egypt
Kafrelsheikh University