The Effect of Vitamin K Supplementation on Glucose Metabolism
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- AIRg (acute insulin response to glucose) using FSIGT (frequently sampled intravenous glucose tolerance test)
研究概览
简要总结
The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response.
详细描述
Recently, many studies have reported that vitamin K metabolism is related to glucose metabolism. The suggested mechanisms connecting vitamin K metabolism and glucose metabolism, are inflammation responses and osteocalcin effect on glucose metabolism. Most of the studies have investigated fasting glucose and insulin sensitive index, few have assessed glucose-intake-stimulated responses in regard to vitamin K supplementation. The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response using intravenous glucose tolerance test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy male volunteer older than 20 years
排除标准
- •Subjects with (a history of) diabetes
- •Subjects receiving medication related to diabetes or obesity
- •Subjects receiving warfarin
研究组 & 干预措施
Vitamin K
Vitamin K supplementation (menatetrenone 30 mg, 3 times a day for 4 weeks)
干预措施: Menatetrenone (Drug)
Placebo control
Placebo control
干预措施: Placebo (Drug)
结局指标
主要结局
AIRg (acute insulin response to glucose) using FSIGT (frequently sampled intravenous glucose tolerance test)
时间窗: 4 weeks later
次要结局
- beta-cell function (FSIGT)(4 weeks later)
- disposition index (FSIGT)(4 weeks later)
- insulin sensitivity (FSIGT)(4 weeks later)