Changes in Food Preference and Food Cue Responsivity After Bariatric Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 3
- 主要终点
- Change in brain reward response to food cues
研究概览
简要总结
It has been suggested that obese people are more sensitive to sensory and rewarding effects of food, aspects that mediate food preferences and intake. Individuals that underwent Roux-en-Y gastric bypass surgery frequently report changes in food preference. They indicate a decreased preference for highly rewarding energy dense foods. Changes in food preference might be related to alterations in central (brain) mechanisms, related to reward sensing. The smell and sight of food can be considered as anticipatory cues for the rewarding effects of food intake. The aim of this study is to determine the effect of gastric bypass surgery on (alterations in) food preferences. Secondly, this study aims at assessing the effect of gastric bypass surgery on the brain reward response when exposed to sight and smell of food stimuli with different sugar and fat contents.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Scheduled for Roux-en-Y Gastric Bypass Surgery at Rijnstate hospital
排除标准
- •Lack of appetite
- •Having difficulties swallowing/eating
- •Being a vegetarian
- •Allergic to food product used as stimuli in the study
结局指标
主要结局
Change in brain reward response to food cues
时间窗: Before and 2 months after surgery
Two weeks before and two months after Roux-en-Y Gastric Bypass the brain reward response to the sight and smell of food will be assessed in a subset of 30 participants.
Development of food preferences after Roux-en-Y gastric bypass surgery
时间窗: Participants will be followed for two years after they undergo surgery
Food preferences will be assessed 2 weeks before Roux-en-Y Gastric Bypass surgery and 2 months, 1 year and 2 years after surgery.
次要结局
- Plasma levels of endocannabinoids and satiety hormones(Before and 2 months after surgery)