A Comparative study of effect of administration of Ketamine and Paracetamol versus Paracetamol on postoperative pain, nausea and vomiting after pediatric Adenotonsillectomy

This will be a hospital based prospective, randomized, double blind study conducted to compare the efficacy of administration of Ketamine and Paracetamol versus Paracetamol on postoperative pain, nausea, vomiting after pediatric adenotonsillectomy. For this study pediatric population is between 3 to 12 years of age group ASA grade 1 or 2 with exemption of all the exclusion criteria mentioned above and undergoing adenotonsillectomy under general anesthesia. The primary objective of the study is to assess the postoperative 12-hour pain score after administrating the drugs. The secondary objective of the study is to assess the duration of analgesia, episodes of nausea and vomiting, hemodynamic status before and after giving the analgesics and any complication associated. Participants will be allocated in two different group each with 40 number sample size. Group KP will receive Injection Ketamine (0.25mg/kg) with Paracetamol (15mg/kg) intravenously and group P will receive injection Paracetamol (15mg/kg). Both the drugs are administrated 15 minutes prior to the extubation. Preanesthetic evaluation will be done on the day before surgery. Since the patient enrolled in the surgery were children, patents need to give full information regarding the study with informed risk consent. All preparation for general anesthesia with emergency cart will be kept ready in prior. Child will be induced after proper preoxygenation and premedication and later with muscle relaxant in adequate dosage at optimum depth of anesthesia. Child will be administrated with above mentioned drugs 15 minutes prior to extubation. Patient will be monitored intraoperatively and postoperatively upto12 hours at pre described time interval and documented. Data will be analyzed statistically using standard quantitative and qualitative tests.