TCTR20190127003招募中未知
Effectiveness of 7-day and 14-day high-dose PPI bismuth-containing quadruple therapy with probiotics supplement for Helicobacter pylori eradication: A double blinded-randomized placebo-controlled study
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 80 Years（—）
- 性别
- All
入选标准
- •1.Having abdominal pain which was indicative for assessing with esophagogastroduodenoscopy consistent with The Gastroenterological Association of Thailand(12) as followed;
- •â€¢Coexisting with dysphagia
- •â€¢Evidence of gastrointestinal blood loss such as previous history of bloody vomiting, melena and iron deficiency anemia
- •â€¢Unexplained weight loss such as unintended weight losing, recent diagnosis of diabetes mellitus or thyrotoxicosis
- •â€¢Persistent vomiting
- •â€¢Age onset of symptoms > 50 years old without any explainable causes including drugs and food
- •â€¢Progressive or recurrent symptoms after adequate medical treatments
- •2.Detecting for H. pylori infection with positive urease test and/or pathological findings of H. pylori and/or positive cultures
- •3.Having written informed consent for all participants.
排除标准
- •1.Any cases with upper gastrointestinal bleeding
- •2.Being treated with medications affecting the research outcome, for example, by using antibiotics including amoxicillin, clarithromycin, tetracycline or metronidazole within 1 month before the enrollment
- •3.Having contraindication to gastric biopsy such as coagulopathy
- •4.Any history of drug allergy for Tetracycline, Metronidazole, Bismuth, and Dexlansoprazole
- •5.Receiving proton pump inhibitor or receiving any antibiotics or bismuth within 4 weeks or consumption of probiotic products within 2 weeks.
- •6.Being pregnant or raising children with breast-feeding
- •7.Having history of H. pylori eradication treatment
- •8.Having severe underlying disease including end-stage renal disease requiring hemodialysis or peritoneal dialysis (GFR < 15), cirrhosis with Child-Pugh classification grade C, immunocompromised host with AIDS, malignancy and/or bed ridden cerebrovascular disease.
- •9.Any cases who receiving anticoagulant
- •10.Having previous gastric surgery
- •11.Unwilling to participate into research
- •12.Having history of taking previous medications which interacted with the research treatment
- •13.Having a medication that causes drugs to drugs interaction with a research medication
研究者
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