The Effects of Sufentanil-remimazolam vs. Remifentanil-remimazolam Total Intravenous Anesthesia on Postoperative Pain in Laparoscopic-assisted Gastrectomy - A Randomized, Controlled Study-
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Total consumption of fentanyl in 24 hours after surgery
研究概览
简要总结
In this study, the investigators evaluate the effect of total intravenous anesthesia using sufentanil-remimazolam and remifentanil-remimazolam on postoperative pain in patients undergoing laparoscopic gastrectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •20years or older
- •Scheduled for laparoscopic-assisted gastrectomy
- •American Society of Anesthesiologists(ASA) physical status I and III
排除标准
- •Emergency operation
- •Patients with a history of severe hypersensitivity reaction to dextran 40
- •Patients who cannot use patient controlled analgesia(PCA)
- •Patients with morbid obesity [body mass index (BMI) >35 kg/m2]
- •Patients with history of uncontrolled hypertension (diastolic BP >110mmHg) or DM
- •Patients with history of heart failure (unstable angina, congestive heart failure)
- •Patients with history of liver failure, renal failure, allergic to medicine
- •Patients with history of cerebrovascular disease (cerebral hemorrhage, cerebral ischemia)
- •Patients with history of uncontrolled psychiatric disease (PTSD, anxiety, depression)
- •Patients with obstructive sleep apnea
- •Patients who cannot read the consent form (examples: Illiterate, foreigner)
- •Patients who withdraw the consent
研究组 & 干预措施
Sufentanil-remimazolam group
The sufentanil-remimazolam group receives total intravenous anesthesia with sufentanil-remimazolam.
干预措施: sufentanil-remimazolam group (Drug)
Remifentanil-remimazolam group
The remifentanil-remimazolam group receives total intravenous anesthesia with remifentanil-remimazolam.
干预措施: remifentanil-remimazolam group (Drug)
结局指标
主要结局
Total consumption of fentanyl in 24 hours after surgery
时间窗: after 24 hours postoperative period
To investigate the effect of total intravenous anesthesia with intraoperative sufentanil-remimazolam and remifentanil-remimazolam on postoperative pain, total cumulative dose of fentanyl was measured for the first postoperative 24 hour.
次要结局
未报告次要终点