Hemodynamic Modulations to Ameliorate Sinusoidal Injuries After Extended Liver Resections: the Role of Splenic Artery Ligation and Porto-caval Shunt in a Series of Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- portal vein flow
研究概览
简要总结
Our study aimed at assessing the changes of portal vein pressure, portal vein flow and hepatic arterial flow (HAF) in liver remnants ≤ 30% of the standard liver volume by reducing portal vein overflow via ligation of the splenic artery.
详细描述
It has been reported that prevention of acute portal overpressure in small-for-size liver grafts leads to better postoperative outcomes. Accordingly, we aimed to investigate the feasibility of the technique of splenic artery ligation in a case series of patients subjected to major liver resections with evidence of small-for-size syndrome and whether the maneuver results in reduction of portal venous pressure and flow.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients
- •American Society of Anesthesiologists (ASA) distribution I to III
- •Patients scheduled for major liver resection (≥4 segments)
排除标准
- •patients with extrahepatic disease
- •patients with metastatic liver tumors
结局指标
主要结局
portal vein flow
时间窗: through the operation, an average period of two hours
change of portal vein flow from before liver resection to after reperfusion of the liver remnant
hepatic artery flow
时间窗: through the operation, an average period of two hours
change of hepatic artery flow from before liver resection to after reperfusion of the liver remnant
portal vein pressure
时间窗: through the operation, an average period of two hours
change of portal vein pressure from before liver resection to after reperfusion of the liver remnant
次要结局
未报告次要终点
研究者
Dr Kassiani Theodoraki
Professor of Anesthesiology
Aretaieion University Hospital