A Pragmatic Randomized Controlled Study on the Efficacy of Intravenous versus Peri-tumoral Lignocaine Administration in Attenuating Pro- metastatic Biomarkers in Breast Cancer Patients undergoing Resection: a Step Towards Reducing recurrence

This randomized controlled trial will be conducted at the All India Institute of Medical Sciences (AIIMS) Bhopal, involving departments of anesthesiology, biochemistry, surgery, oncosurgery and translational Medicine. The study will include three parallel arms: IV lignocaine infusion, peri-tumoral lignocaine infiltration, and a control group. A total of 105 patients will be enrolled, with 35 patients in each group. Block randomization will ensure balanced distribution across tumour subtypes. The IV lignocaine group will receive a weight based lignocaine bolus 10 minutes prior to incision followed by continuous infusion until skin closure, while the peri-tumoral group will receive a similar bolus injected around the tumor 10 minutes prior to incision. The control group will receive normal saline. All the groups will also receive evidence based standardised surgical and anesthesia care as defined in the study protocol. Biomarker levels will be measured using commercial ELISA kits, and patients will be followed for at least two years for cancer recurrence.