Influence de la kinésiophobie Sur l'excitabilité Des Connexions pariéto- Frontales au Cours d'un Mouvement de Pointage Chez l'Homme

This work will focus on a population of 30 healthy volunteer subjects who will be recruited via a posting within the Faculty of Sports Sciences of Lille, the University of Littoral Côte d'Opale and Eurasport. Compensation of 50 euros per subject is provided for participation in the study.

All these criteria will be reviewed during the visit to the clinical neurophysiology department during which each subject will be seen in an interview with a neurologist (Pr. Arnaud Delval, PU-PH of the clinical neurophysiology department of Lille University Hospital) before the start of the investigations. Explorations may be stopped at any time upon simple request from the participant. Each subject may leave the study by decision of the competent administrative authority, the promoter and the coordinating investigator but also by decision of a co-investigator or by decision of the interested party himself in accordance with the regulations and as mentioned in the consent. The data recorded in subjects who decide to leave the study will be partial and not exploitable, it will therefore be destroyed.

In this study, the impact of induced kinesiophobia on the functional connectivity between the PPC (posterior parietal cortex) and M1 (primary motor cortex) in healthy subjects during the preparatory phase of a pointing task will be assessed. Participants will undergo three transcranial magnetic stimulation (TMS) sessions.

The first session will be designed to define the optimal inter-stimulus intervals (ISIs) between both paired-pulses, with the conditioned stimulus (CS) applied to the PPC and the test stimulus (TS) applied to the M1. The second session will aim to define the optimal delay between the pointing start command (indicated by light signals) and the TS pulse over M1. The last session will determine whether a pointing start command related to a threat (indicated by a red light signal) has a different impact than a neutral pointing start command (indicated by a green light signal) on the functional connectivity between the PPC and M1.

To assess the personality of participants concerning kinesiophobia and fear-avoidance, participants will respond to two online questionnaires using RedCap, the Research Electronic Data Capture system. The questionnaires include the Tampa Scale for Kinesiophobia French version (TSK-CF) and the Fear-Avoidance Components Scale French version (FACS-Fr).