Association of Postoperative Lactate Levels With Postoperative Atrial Fibrillation in Patients Undergoing Isolated Coronary Artery Bypass Graft Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Postoperative atrial fibrillation
研究概览
简要总结
Postoperative atrial fibrillation (POAF) is associated with increased mortality and morbidity in patients undergoing isolated coronary artery bypass grafting (CABG). It has been estimated that 5-40% of CABG patients experience POAF. Advanced age, P wave abnormalities, left atrial dilation, emergency surgery, low left ventricle ejection fraction, low glomerular filtration rate and chronic obstructive pulmonary disease have been reported in the etiology. Predicting which patients would experience POAF following CABG is important since it would allow physicians to apply more focused prophylactic measures. Lactate is the final product of anaerobic glycolysis. Serum lactate level are increased in case of inadequate oxygen delivery to tissues. The investigators aim to assess whether serum lactate levels measured early in the postoperative period could be used as a predictive marker of POAF in adults undergoing isolated CABG.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Undergoing isolated CABG
- •Age >18 years
排除标准
- •Age <18 years
- •Pregnancy
- •History of paroxysmal atrial fibrillation prior to surgery
- •Undergoing concomitant procedures (e.g., CABG + valve surgery)
- •Any preoperative cardiac rhythm other than normal sinus rhythm
- •More than mild cardiac valve stenosis or insufficiency
结局指标
主要结局
Postoperative atrial fibrillation
时间窗: 30 days
New-onset atrial fibrillation occurring in the immediate period after CABG
次要结局
未报告次要终点
研究者
Zeki Temiztürk
Principal Investigator
Başakşehir Çam & Sakura City Hospital
