Investigation of Gait Parameters in Health and Neurological Disease Under Varying Locomotor Conditions
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 208
- 试验地点
- 1
- 主要终点
- Change of gait parameter after injury to CNS
研究概览
简要总结
In the cross-sectional component of this study, our overall objective is to gather a large pool of data from which we can generate gait "profiles". These profiles will consist of a constellation of gait (+/- electrophysiological) parameters associated with a particular neurological diagnosis or specific lesion(s) in neuroanatomical systems. Once developed, these profiles can be compared for differences and similarities; allowing insights into the specificity of the effect on gait of a given diagnosis or lesion in the case of the former and redundancy of neuroanatomical systems in that of the latter. A longitudinal component of the study will look at the evolution of gait parameters over time in a group of patients with spinal cord injury.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 18 - 80
- •written, informed consent
- •one of the following established diagnoses: unilateral stroke affecting motor system, Parkinson syndrome, cerebellar disease, vestibular dysfunction, spinal cord injury, multiple sclerosis
- •Brain and whole spine T1, T2 & FLAIR magnetic resonance imaging performed within the last four months and available for study purposes or no contraindications to performing these scans
- •Healthy subjects:
- •age 18 - 80
- •written informed consent
排除标准
- •Colour-blindness
- •Known to be pregnant or breastfeeding
- •Body mass index (weight in kg/height in metres squared) >40 Unable to walk 50m within 6 minutes (with or without walking aids) Inability to undertake any component of the trial protocol
- •Terminal diagnosis with life expectancy less than six months
- •Cognitive disturbance defined as MMSE < 25 Clinically significant comorbidities such as severe cardiovascular, pulmonary or malignant disease
- •Healthy subjects:
- •Colour-blindness
- •Known to be pregnant or breastfeeding
- •Body mass index (weight in kg/height in metres squared) >40 Unable to walk 50m within 6 minutes
- •Reliance on walking aids / prostheses for mobilisation
- •Significant neurological or orthopaedic diagnosis with potential impact on gait // Previous operations on the lower limbs or spine with potential impact on gait Inability to undertake any component of the trial protocol Clinically significant conditions such as severe cardiovascular, pulmonary or malignant disease
结局指标
主要结局
Change of gait parameter after injury to CNS
时间窗: Timepoint 0 plus timepoint 6 months and 12 months
次要结局
未报告次要终点