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临床试验/NCT04715919
NCT04715919已完成不适用

Long Term Outcomes in Patients With Coronavirus Disease-19 (COVID-19) on Pulmonary Functions, Exercise Capacity, Lung Structure and Quality of Life

Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2021年1月15日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
70
试验地点
1
主要终点
Structural Change in Lung

研究概览

简要总结

The investigators hypothese that lung involvement due to COVID-19 may cause structural changes in the lung in the long term. In this study the effects of structural changes in the lung on pulmonary function tests, exercise capacity and quality of life will be examined.

详细描述

Coronavirus disease-19 (COVID-19) has a clinical spectrum ranging from asymptomatic cases to severe cases requiring intensive care hospitalization due to respiratory failure. The disease mostly infects the lower respiratory tract. Typical computed tomography findings of lung involvement are bilateral, peripherally located ground glass density and consolidations. There is a close relationship between tomography findings and clinical severity. It is not known whether there will be complete recovery in the lungs.

Investigators will evaluate pulmonary structures with chest computed tomography, respiratory capacity with pulmonary function tests (PFTs), exercise capacity with six minutes walk test and quality of life with short form-36 (SF-36) im patients who survivors of COVID-19 at least 6 months after hospital discharge.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 90 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients who were ≥18 years
  • COVID-19 confirmed by Real-Time PCR
  • At least 6 months after discharge

排除标准

  • Patients who were < 18 years
  • Pregnancy
  • Become bedridden after discharge

结局指标

主要结局

Structural Change in Lung

时间窗: up to 6 months after discharge

Chest Computed Tomography

次要结局

  • Short Form Health Survey Score (SF-16)(up to 6 months after discharge)
  • Carbon monoxide diffusion capacity (DLCO)(up to 6 months after discharge)
  • Exercise Capacity(up to 6 months after discharge)

研究者

发起方
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Cenk Kirakli, M.D.

Professor Doctor

Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital

研究点 (1)

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