NCT00612079已完成不适用
The Effect of Sertindole on Sensory Gating and Cognition in Healthy Volunteers
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Sensory (EEG: P50 suppression) and sensorimotor gating (EMG: PPI)
研究概览
简要总结
This study aims to further validate and extend our previous findings insofar that the effect of the atypical antipsychotic and mixed 5-HT2/D2 antagonist sertindole on sensorimotor gating processes and its relationship to cognitive performance shall be explored.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age: 18-40
- •Gender: male
排除标准
- •Axis I Disorders: lifetime DSM IV diagnosis according to DIA-X of alcohol or illicit drug dependence. No life-time DSM IV diagnosis according to DIA-X of a major affective, psychotic, anxiety disorder, eating-disorder as defined above.
- •Axis II Disorders: lifetime DSM IV diagnosis of personality disorder according to SCID-II.
- •Family history: lifetime history of 1st degree relative (parents and siblings) of a major affective, psychotic, or anxiety disorder as defined above.
- •ECG: QTc-interval >450 msec.
- •Systolic blood pressure <100 mmHg
- •Bradycardia (Hf < 50/Min) und Arrhythmias
- •Hypokalemia or Hypomagnesemia
研究组 & 干预措施
2
Experimental
Healthy volunteers with high sensory gating levels.
干预措施: Placebo (Drug)
1
Experimental
Healthy volunteers with low sensory gating levels.
干预措施: Placebo (Drug)
2
Experimental
Healthy volunteers with high sensory gating levels.
干预措施: Sertindole (Drug)
1
Experimental
Healthy volunteers with low sensory gating levels.
干预措施: Sertindole (Drug)
结局指标
主要结局
Sensory (EEG: P50 suppression) and sensorimotor gating (EMG: PPI)
时间窗: after placebo and and after medical treatment
次要结局
- Cognitive performances(after placebo and and after medical treatment)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Effects of Sensory Flicker and Electrical Flicker StimulationBrain DiseasesNCT04188834Emory University23
已完成
不适用
Treatment With Spinal Cord Stimulation: Effect on Sensory ParametersChronic PainNCT01261468Danish Pain Research Center15
已完成
4 期
Memantine Effects on Sensorimotor Gating and Neurocognition in SchizophreniaSchizo Affective DisorderHealthySchizophreniaSchizoaffective DisorderNCT03860597University of California, San Diego42
已完成
不适用
Cortico-cortical Connectivity During Midazolam Sedation in Humans; a TMS/EEG StudyHealthyNCT00734006University of Wisconsin, Madison20
尚未招募
不适用
The effect of implementing sensory stimulations program on clinical outcomes of brain injury patients admitted in Intensive Care UnitCondition 1: Head trauma. Condition 2: Head trauma. Condition 3: Head trauma. Condition 4: Head trauma. Condition 5: Head trauma. Condition 6: Brain Injury.Focal traumatic brain injuryDiffuse traumatic brain injuryEpidural hemorrhageTraumatic subdural hemorrhageTraumatic subarachnoid hemorrhageIntracranial injuryS06.3S06.2S06.4S06.5S06.6IRCT20120414009469N4Ahvaz University of Medical Sciences66