NCT07588295招募中不适用
Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease: the LAST-COP Study
Maria Cecilia Hospital1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2024年3月18日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
研究概览
简要总结
Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages.
This study aims to evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions, and to correlate these findings with the distribution of circulating monocyte subpopulations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with chronic coronary artery disease;
- •Patients with no-ST elevation acute coronary syndrome;
- •Patients with chronic claudication (Rutherford II-III)
- •Patients with critical limb ischemia (Rutherford IV-V).
排除标准
- •Severe renal dysfunction
- •Severe valve disease
- •Advanced heart failure
- •Advanced liver disease
- •Chronic inflammatory or autoimmune disease
- •Use of antinflammatory drugs
- •Acute infection
- •Recent surgical procedures
研究者
研究点 (1)
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