NCT02859675已完成不适用
Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Modification of sweet taste
研究概览
简要总结
This study will improve our understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups. The practical spin-off from this research is potentially very important for the management of nutritional disorders associated with the disease by guiding diets towards foods that correspond to patients' preferences and/or to modified tastes. In addition, the results could lead to the identification of sensory markers that herald an inflammatory flare-up of the disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age between 18 and 60 years,
- •Diagnosis of Crohn's disease according to clinical, endoscopic, histological, radiological and biochemical criteria as defined by the European Consensus Conference,
- •Men or women who have provided consent and willing to cooperate.
排除标准
- •Chronic inflammatory intestinal disease (CIID) other than Crohn's disease: haemorrhagic rectocolitis, undetermined colitis, microscopic colitis.
- •Intercurrent disease (diabetes and metabolic disease, liver cirrhosis, progressive cancer, acute or chronic infection, Human Immunodeficiency Virus HIV),
- •Organ failure (respiratory, heart, or renal failure, neurological disorders),
- •Intolerance to gluten,
- •Treatments (other than those used for Crohn's disease) able to interfere with food intake,
- •Aversion to foods consumed or smelled,
- •Poor understanding of cognitive tasks required.
- •Crohn's disease complicated by an abscess or infectious complication
- •Acute Crohn's disease defined by a CDAI score > 150
- •For Controls:
- •Inclusion Criteria:
- •Adult person
- •Without follow-up for a chronic pathology
- •Having given its consent
- •Exclusion Criteria:
- •Protected adult
- •Person not affiliated to a social security system
- •Pregnant or breastfeeding woman
- •Active smoker
- •No one who does not speak French
- •Taking treatment that interferes with taste or acts on the central nervous system
结局指标
主要结局
Modification of sweet taste
时间窗: through the study completion up to 10 years
the measurement of detection thresholds consists in presenting to the participants in order of increasing concentrations, series of forced-choice triangular tests
次要结局
未报告次要终点
研究者
研究点 (1)
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