Eating Behaviour and Gustatory Sensitivity Before and After Liver Transplant in Cirrhotic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 73
- 试验地点
- 2
- 主要终点
- Change in respiratory quotient (RQ) by indirect calorimetry compared with baseline values
研究概览
简要总结
Today, we know that olfactogustatory alterations occur in cirrhotic patients before the liver transplant but no study has been conducted to show eventual disturbances after the transplantation able to explain modifications in eating behaviour. In parallel, the metabolic status, itself dependent on liver metabolism, influences food preferences and is modified after the transplantation as the liver recovers its ability to store glycogen, but is not able to inform the brain as the afferent nerve impulses have been suppressed. The innovative aspect of this project is to provide information on the importance of the liver in the regulation of energy homeostasis.
The results of this study will improve our understanding of eating behaviour and olfactogustatory sensitivity and allow us to orient liver transplant patients towards appropriate diets.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •persons who have provided written informed consent
- •persons aged between 18 and 70 years
- •persons waiting for a liver transplantation (group LT)
- •persons with stable liver damage
- •persons waiting for a kidney transplantation (KT)
- •healthy subjects (control group) no known disease
排除标准
- •persons without national health insurance cover
- •persons with chronic infection,
- •persons with acute infection,
- •persons with progressive cancer,
- •persons with an antibiotic treatment,
- •persons who drink alcohol,
- •pregnant or breast-feeding women,
- •persons with an aversion to the foods proposed in the study,
- •persons taking treatments known to interfere with gustatory and olfactory performance,
- •adults under guardianship
结局指标
主要结局
Change in respiratory quotient (RQ) by indirect calorimetry compared with baseline values
时间窗: At month 0, month 3, month 9 and month 15
Change in olfactory liking compared with baseline values by questionnaire
时间窗: At month 0, month 3, month 9 and month 15
次要结局
未报告次要终点