Compensatory Training to Support Everyday Function and Adherence to Brain Healthy Lifestyle Changes in Those at Risk for Alzheimer's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- BrainHQ
研究概览
简要总结
The Researchers are trying to better understand if behavioral interventions can help improve memory compensation and engagement in healthy lifestyle behaviors in those with memory concerns but normal mental status exam.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 50 or older
- •A positive complaint or concern in response to two questions ('Do you feel like your memory or other aspects of thinking are becoming worse?' and 'Does this worry you?')
- •Normal cognitive performance on the Montreal Cognitive Assessment (adjusted for age and education)
- •Self-reported independent function in daily life as measure by the Lawson IADL scale (IADL=8)
- •English speaking
- •Approval letter from a physician (due to the exercise component)
排除标准
- •Known neurological disorder with potential cognitive symptoms (a diagnosis of Parkinson's disease, epilepsy, a history of significant TBI, etc.)
- •Uncontrolled moderate or severe depression (e.g., CES-D > 21).
结局指标
主要结局
BrainHQ
时间窗: baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months
Number of minutes on BrainHQ computer exercise program
Everyday Compensation Questionnaire
时间窗: baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months
self-report and informant report if an informant is available of compensatory strategy use; range 0-148 with higher scores indicating more compensatory use
Lifestyle Activities Questionnaire
时间窗: baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months
self-report of cognitive activities, range 13-65 with higher scores indicating more activity
Mindful Attention Awareness Scale
时间窗: baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months
self-report of mindfulness, range of 11-66 with higher scores indicating more mindful daily experience
Physical Activities Questionnaire
时间窗: baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months
self-report of physical activity; scores include number of days per week across 7 activity types and number of minutes in each activity when completed.
次要结局
- Quality of Life (in aging and cognitive health)(baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months)
- Psychological well-being(baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months)
- cognitive measure of executive functioning(baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months)
- cognitive measure of verbal fluency(baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months)
- Everyday Cognition(baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months)
- Centers for Epidemiological Studies - Depression(baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months)
- Cognitive measure of memory(baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months)
- cognitive measure of response inhibition(baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months)
- cognitive measure of visual scanning speed(baseline, change from baseline at end of 10 week treatment, change from baseline at 3 months, change from baseline at 6 months)
研究者
Dona E. Locke
Principal Investigator
Mayo Clinic