Ovulation Trigger With hCG Compared to GnRH Agonist in Patients With Repeated IVF Failures
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 3
- 试验地点
- 1
- 主要终点
- Fetal Heart Activity 1 Month After Oocyte Retrieval
研究概览
简要总结
Ovulation trigger is needed in in vitro fertilization (IVF) to get mature eggs. Routinely, human chorionic gonadotropin (hCG) is used for that purpose given its similarity to the natural hormone that does this job in a natural cycle (luteinizing hormone, LH). In a natural cycle another hormone takes part in the process (follicle stimulating hormone, FSH). To induce a natural-like ovulation surge that includes LH and FSH , gonadotropin releasing hormone (GnRH) agonist can be given.
The purpose of this study is to find out which approach may work better in IVF patients who experienced 4 IVF failures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 44 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •IVF patients with at least 4 consecutive failures.
- •On trigger day, no more than 10 follicles of 12 mm and up
排除标准
- •History of moderate or severe OHSS.
研究组 & 干预措施
hCG trigger
Ovulation trigger with Ovitrelle 250 microgram, luteal support with vaginal progesterone: gel Crinone 8% daily.
干预措施: hCG trigger (Drug)
GnRH agonist trigger
ovulation trigger with Decapeptyl 0.2 mg, luteal support with 2 injections of 1,500 U hCG.
干预措施: GnRH agonist trigger (Drug)
结局指标
主要结局
Fetal Heart Activity 1 Month After Oocyte Retrieval
时间窗: 1 month after oocyte retrieval
Fetal heart activity as seen by vaginal ultrsound imaging 1 month after oocyte retrieval
次要结局
- Patients Comfort During the Luteal Phase(During 2 weeks from day of oocyte retrieval)
研究者
Shahar Kol MD
Director, IVF Unit
Rambam Health Care Campus