EUCTR2012-000215-89-IT进行中（未招募）不适用
Effects of ivabradine on vascular function in individuals at increased risk of developing cardiovascular disease and with impaired endothelial functionAn international, multicentre, randomised, double-blind, placebo-controlled study over 12 weeks.
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 340
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •- Men or postmenopausal women of any ethnic origin aged between 21 and 74 years
- •- In sinus rhythm with resting HR at least 75 bpm
- •- At increased risk of subsequent cardiovascular disease (documented by the presence of at least two cardiovascular risk factors such as diabetes, hypertension, smoking, hypercholesterolemia) and impaired FMD (<5.0%)
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 270
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 70
排除标准
- •- Previous diagnosis of coronary heart disease
- •- Previous diagnosis of heart failure or current clinical signs or symptoms in keeping with a diagnosis of heart failure
- •- History of cerebrovascular or peripheral arterial disease
- •- Uncontrolled hypertension
- •- Chronic infectious or inflammatory disease
- •- Chronic Obstructive Pulmonary Disease (COPD) treated with inhaled bronchodilators
- •- Malignancy
- •- Current therapy with nicorandil, nitrate, insulin
- •- Contra-indication to ivabradine
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