Collecting reference values for arterial stiffness and insulin resistance in healthy adolescents - Stiffness of the Arteries and Insulin Resistance in healthy Adolescents

Sint Antonius Ziekenhuis0 个研究点目标入组 147 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•- Subjects age * 10 and < 20 years.
•- BMI-SDS > -1.1 and <1.1 (normal weight).
•- Caucasian descent.
•- Signed informed consent from subjects and parents/caregivers (if applicable).

•- Absence of a venous cannula for scheduled surgery.
•- Presence of T1DM or T2DM.
•- Hypertension defined as blood pressure >p95 for age, sex and height.
•- Use of corticosteroids, antihyperglycaemic drugs and/or antihypertensive drugs. ;To make sure that the measurements will not be influenced by renal insufficiency the glomerular filtration rate (GFR) will be measured. Also to make sure that the subjects will not have infections that influence the PWV, CRP will be measured. Subjects will be excluded if:
•- GFR < 80 ml/min.1,73m² (GFR=40*length(cm)/serumcreatinin (*mol/l)
•- C-reactive protein concentration >10 mg/l

发起方