NCT03084042Unknown不适用
Emotional Brain Networks & Cognitive Functioning in Depression and Anxiety
University of Electronic Science and Technology of China1 个研究点 分布在 1 个国家目标入组 105 人开始时间: 2016年7月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- Brain activity in the emotional and cognitive core regions of the brain as assessed by fMRI
研究概览
简要总结
This study aims to 1) examine common and specific emotional and cognitive dysfunctions between Major Depression and generalized anxiety disorder; 2) Examine emotional and cognitive dysfunctions between the two disorders and healthy controls; 3) Examine the biomarkers predicting successful therapy or not.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of Generalized Anxiety Disorder (GAD) according to DSM V criteria in a structured clinical interview for DSM-V Axis I disorders (SCID I; APA, 2014) and a confirmatory clinical interview
- •Duration of the current episode > 3 weeks
- •Diagnosis of current major depressive disorder in a structured clinical interview for DSM-V Axis I disorders (SCID I; APA, 2014) and a confirmatory clinical interview
- •Duration of the current episode > 4 weeks
排除标准
- •GAD: diagnosis of any other psychiatric Axis I disorder (except GAD) as a principal diagnosis within the past six months
- •MDD: diagnosis of any other psychiatric Axis I disorder (except MDD) as a principal diagnosis within the past six months
结局指标
主要结局
Brain activity in the emotional and cognitive core regions of the brain as assessed by fMRI
时间窗: 1 hour (assessed at study inclusion)
fMRI based indices during working memory
次要结局
- Behavioral performance during the fMRI: working memory(1 hour (assessed at study inclusion))
- Symptom improvement after 3 months: depression(3 months)
- Behavioral performance during the fMRI: face processing(1 hour (assessed at study inclusion))
- Behavioral performance during the fMRI: empathy reactivity(1 hour (assessed at study inclusion))
- Cognitive performance at study inclusion(1 hour (assessed at study inclusion))
- Symptom improvement after 3 months: anxiety(3 months)
研究者
Benjamin Becker
Professor
University of Electronic Science and Technology of China
研究点 (1)
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