Iodine Status in Pregnant Women in Israel
试验速览
- 阶段
- 不适用
- 入组人数
- 160
- 试验地点
- 2
- 主要终点
- Evaluation of average iodine consumption in food
研究概览
简要总结
Worldwide Data suggest that Iodine deficiency is a concern among healthy pregnant women. Thus, screening first trimester healthy pregnant women for iodine status is of clinical value for mother and child as iodine deficiency might have implications on thyroid function as well as pregnancy outcomes
详细描述
New emerging data suggest pregnant women in Israel are iodine deficient in the first trimester of pregnancy. This is of major concern as first trimester iodine sufficiency is critical for the development of the fetal brain. Our aim is to evaluate iodine consumption in first trimester pregnant women in Israel through dietary questioners, Urinary iodine samples and thyroid functions test assessed through blood samples. All data will be analyzed in a central lab.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •First trimester pregnant women with a singleton pregnancy
排除标准
- •Women with a known thyroid disease treated or untreated
- •Women who received contrast material in the year previous to the study
- •women with any chronic disease
- •Women who receive chronic medication not including vitamins
结局指标
主要结局
Evaluation of average iodine consumption in food
时间窗: 1 year
Iodine consumption will be evaluated trough detailed food questionnaires. Data will be quantified and reported in micrograms per day
Evaluation of urinary iodine concentration
时间窗: 1 year
Women will give a spot urine sample for urinary iodine concentration measurement. All data will be analyzed and reported in micrograms/L. Data obtained will be compared to World Health Organization requirements
Thyroid function test measurement
时间窗: 1 year
Thyroid function will be evaluated through blood tests in the first trimester of pregnancy. Data will be analyzed in accordance with local guidelines.
次要结局
未报告次要终点
研究者
Dr. Viviana Ostrovsky
Principal Investigator, Senior Physician, Endocrinology Department
Clalit Health Services