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临床试验/NCT06242015
NCT06242015已完成不适用

The Effect of Ordered Eating on Postprandial Glucose and Substrate Utilization During an Acute Exercise Bout

Old Dominion University2 个研究点 分布在 1 个国家目标入组 23 人开始时间: 2024年2月6日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
23
试验地点
2
主要终点
Postprandial glucose

研究概览

简要总结

There is well documented evidence that ingesting dietary carbohydrate in large amounts tends to increase postprandial glucose. In healthy populations, this is not necessarily a problem, but continuous exposure to high levels of glucose-hyperglycemia-is a defining characteristic and risk factor for type 2 diabetes mellitus. Consuming a carbohydrate-rich food as the final food in a meal sequence has been shown to significantly reduce postprandial glucose excursions in both diabetes patients and in healthy controls. The exact mechanisms behind this phenomenon are not well understood, but one proposed course is simply that the vegetable and protein already being digested slows the rate of glucose rise.

Despite the findings, little-to-no research has examined how manipulating the order of foods in a meal impacts subsequent exercise responses. In this experimental crossover study, each participant will undergo two acute feeding conditions (carbohydrate-rich foods first vs. last in a meal), which will be followed by exercise 60 minutes later. We will observe the effects of meal order on postprandial glucose, substrate/fuel utilization, and subjective perceptions at rest and during 30 minutes of exercise.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
All
接受健康志愿者
是

入选标准

  • •Currently physically active (scheduled exercise at least three days per week for 30 minutes each time over the last three months)
  • •Ability to perform moderate-to-high intensity running for at least 30 minutes

排除标准

  • •Any allergy or other condition that would prohibit the consumption of poultry, rice, or broccoli
  • •Any injury or disease (cardiovascular disease, diabetes, pulmonary disease except controlled asthma) precluding physical exercise
  • •Currently pregnant
  • •Implanted electrical devices such as a pacemaker.

研究组 & 干预措施

Carbohydrate-first meal

Experimental

干预措施: Carbohydrate-first meal (Other)

Carbohydrate-last meal

Experimental

干预措施: Carbohydrate-last meal (Other)

结局指标

主要结局

Postprandial glucose

时间窗: 2 hours (premeal and 30, 60, 90, and 120 minutes after eating)

Blood glucose will be measured with fingerstick samples and a portable glucometer

次要结局

  • Hunger-satiety perceptions(2 hours (Premeal and at 15, 30, 45, 60, 68, 78, 88, 120 minutes after eating))
  • Carbohydrate use(100 minutes (premeal and continuously for 90 minutes after eating))
  • Fat use(100 minutes (premeal and continuously for 90 minutes after eating))
  • Rating of perceived exertion(30 minutes (at 8, 18, 28 minutes of exercise))

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Patrick Wilson, PhD

Associate Professor of Exercise Science

Old Dominion University

研究点 (2)

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