A Chronological Study of the Formation of HIV Cellular Reservoirs Through the Expression of Surface Markers on CD4 + T Lymphocytes, Including CD32a
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- Presence of HIV viral sequences in the CD32 + CD4a + T lymphocytes of the patients
研究概览
简要总结
To analyze the HIV viral sequences present in the CD32 + CD4a + T lymphocytes of the patients who have participated in the ANRS 139 TRIO trial, always followed and in virological success, and carrying multi-resistant viruses archived in the HIV cell reservoir, in order to reconstruct the chronology of the installation of this reservoir.
详细描述
Objectives
Principal objective
To analyze the HIV viral sequences present in the CD32 + CD4a + T lymphocytes of the patients who have participated in the ANRS 139 TRIO trial, always followed and in virological success, and carrying multi-resistant viruses archived in the HIV cell reservoir, in order to reconstruct the chronology of the installation of this reservoir.
Secondary objectives
To analyze the HIV viral sequences present in the CD4 + lymphocytes with other membrane HIV reservoir markers, currently being identified, in these same patients
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who participated to ANRS139 TRIO trial, and still followed in centers
- •Who remained in virological success since the participation at the trial: 90% of HIV-1 RNA level less than 50 copies/mL : one or more blips less than 1000 copies/mL are tolerated
- •Genotypic resistance profiles available at baseline and before trial
- •Age ≥ 18 years
- •Affiliate or beneficiary of a social security system (the State Medical Aid or AME is not a social security system).
- •Written informed consent signed by the person and the investigator before any exam performed in the study.
排除标准
- •HIV-1 RNA level ≥ 1000 copies/mL at least once since the end of the 139 TRIO trial
- •Patient participating in another research evaluating other treatments with an exclusion period ongoing at the screening visit.
- •Person under legal guardianship or deprived of liberty by a judicial or administrative decision.
结局指标
主要结局
Presence of HIV viral sequences in the CD32 + CD4a + T lymphocytes of the patients
时间窗: inclusion
次要结局
未报告次要终点