PET/MRI Imaging of Neuraxial Inflammation in Sciatica Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Inflammation in the spine
研究概览
简要总结
The purpose of this study is to see if the spine shows areas of inflammation using a specific type of imaging (pictures).
详细描述
The purpose of this study is to determine if inflammation around the spinal nerves can be identified using a radioactive tracer [11C] PBR28 and integrated PET/MRI scan for the purpose of better treating patients who have radicular lumbar pain with epidural steroid injections.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Healthy
Healthy subjects with no pain.
- Radioactive dye
- PET/MRI
- Blood draw
干预措施: Radioactive dye (Drug)
Healthy
Healthy subjects with no pain.
- Radioactive dye
- PET/MRI
- Blood draw
干预措施: PET/MRI (Radiation)
Healthy
Healthy subjects with no pain.
- Radioactive dye
- PET/MRI
- Blood draw
干预措施: Blood draw (Other)
Sciatica
Subjects with sciatica and scheduled for an epidural steroid injection (ESI).
- Radioactive dye
- PET/MRI
- Blood draw
干预措施: Radioactive dye (Drug)
Sciatica
Subjects with sciatica and scheduled for an epidural steroid injection (ESI).
- Radioactive dye
- PET/MRI
- Blood draw
干预措施: PET/MRI (Radiation)
Sciatica
Subjects with sciatica and scheduled for an epidural steroid injection (ESI).
- Radioactive dye
- PET/MRI
- Blood draw
干预措施: Blood draw (Other)
结局指标
主要结局
Inflammation in the spine
时间窗: 2 hours
The presence of inflammation in the spine using the radioactive tracer \[11C\]PBR28.
次要结局
- Pain Scores on the Visual Analog Scale (VAS)(up to 3 months)
研究者
Yi Zhang, MD
Principal Investigator
Massachusetts General Hospital