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临床试验/NCT01935388
NCT01935388已完成4 期

Common Canister Protocol for Metered Dose Inhaler Administration in Mechanically Ventilated Patients

Barnes-Jewish Hospital1 个研究点 分布在 1 个国家目标入组 354 人开始时间: 2013年6月1日最近更新:
适应症
干预措施

试验速览

阶段
4 期
状态
已完成
入组人数
354
试验地点
1
主要终点
Ventilator-associated pneumonia (VAP)

研究概览

简要总结

Many hospitals employ a common canister inhaler protocol in patients that do not require mechanical ventilator support. Common canister refers to a single inhaler paired with standardized cleaning methods for use on more than one patient. Small reports suggest that this method does not pose an increased infectious risk and is associated with significant cost savings.

Common canister protocols offer a solution to the discordance between inhaler sizes and average inpatient use of the drugs. Metered dose inhaler canisters are contain enough drug for several days to weeks of daily use. However, the average length of stay for most inpatients is only several days. Therefore, most inpatients do not use all of the canister contents, an unused resource that is potentially wasted.

The common canister approach has not been previously described in mechanically ventilated patients (people requiring intensive care unit admission on breathing machines). This study aims to assess the safety of common canister utilization by assessment and comparison of infection rates in the study and control group.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •mechanically ventilated patients prescribed bronchodilator therapy in a medical intensive care unit

排除标准

  • •lung transplant
  • •neutropenic
  • •contact isolation

研究组 & 干预措施

Control

No Intervention

Each patient will be assigned an individual inhaler as per standard of care practice.

Common canister

Experimental

Use of a single MDI (instead of assigning each patient an individual MDI) for multiple mechanically ventilated patients. Inhalers will undergo a stringent cleaning protocol between administrations and storage.

干预措施: Common canister (Other)

结局指标

主要结局

Ventilator-associated pneumonia (VAP)

时间窗: 48 hours after intubation

Pneumonia that developed in association with mechanical ventilation

次要结局

  • Inhaler drug cost(During period of mechanical ventilation, which varies depending on patient's severity of illness and reason for intubation; on average may range from 3-5 days.)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Peggy Watts

MD

Washington University School of Medicine

研究点 (1)

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