Effect of Hydroxycitrate on Urine Chemistry
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- changes in urinary excretion of citrate
研究概览
简要总结
Hydroxycitrate (HCA) is a compound extracted from the fruit, Garcinia Cambogia. Hydroxycitrate supplements are available over the counter and are primarily promoted as a weight loss supplement. There has been recent evidence that hydroxycitrate is a potent inhibitor of calcium oxalate crystal growth and can lead to the dissolution of the crystals. The purpose of this research study is to study the effect of Hydroxycitrate (HCA) supplements on HCA urinary excretion and on urine chemistries in kidney stone formers and normal subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Stone formers group:
- •Established diagnosis of recurrent calcium stone formers
- •Ages between 18 and 80
- •Subjects must be able to read and follow instructions clearly and able to do 24 hour urine collections.
- •Subjects must be voluntarily willing and able to sign an informed consent form.
- •Control Group:
- •In addition to b, c and d above, subjects must not have any known kidney disease or family history of renal stones. Inclusion would be based on information provided by participants.
排除标准
- 未提供
研究组 & 干预措施
Control Group
Participants willrecord a self-selected diet for 3 days and then perform two 24-hour urine collections on the last 2 days of this diet. HCA will be administered afterwards to both groups (see methods below) for 7 days
干预措施: Hydroxycitrate (HCA) (Dietary Supplement)
Calcium Stone Formers
Participants willrecord a self-selected diet for 3 days and then perform two 24-hour urine collections on the last 2 days of this diet. HCA will be administered afterwards to both groups (see methods below) for 7 days
干预措施: Hydroxycitrate (HCA) (Dietary Supplement)
结局指标
主要结局
changes in urinary excretion of citrate
时间窗: 7 Days
Paired t-tests will be performed to compare any changes in citrate before and after the intervention.
次要结局
未报告次要终点