Balance Study on ICU-acquired Hypernatremia and Sodium Handling
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 155
- 试验地点
- 1
- 主要终点
- Sodium balance
研究概览
简要总结
The goal of this study is to find differences between patients who do and do not develop ICU-acquired hypernatremia (IAH). Therefore extended sodium and fluid balances will be performed. Also a couple of other factors that possibly contribute to the development of IAH and/or could give clues about the mechanisms in the development of IAH will be investigated.
详细描述
ICU-acquired hypernatremia (IAH) is common in critically ill patients, but it's aetiology is still not fully understood. Sodium overload and inadequate fluid administration are generally considered important factors, but a previous retrospective study did not reveal differences in sodium or fluid balances between patients who did and did not develop IAH. Because this was retrospective these balances will be prospectively studied in this study to be more sure about the importances of these balances in the development of IAH. Previous studies indicated that (a lot) more factors contribute to the development of IAH. In this study these factors will be investigated, hoping to find differences between patients who do and do not develop IAH.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Predicted duration of ICU-admission >48 hours
排除标准
- •Renal replacement therapy
- •Reason for admission necessitates actively elevation of serum sodium concentration
- •Electrolyte disturbance as reason for admission
- •ICU re-admission within 30 days
- •Referral from another ICU
- •Serum sodium concentration on admission 143mmol/l or above
结局指标
主要结局
Sodium balance
时间窗: During ICU-admission
Differences in sodium balances between patients who do and do not develop IAH
Fluid balance
时间窗: During ICU-admission
Differences in fluid balances between patients who do and do not develop IAH
次要结局
- Kidney function(During ICU-admission)
- Inflammation(During ICU-admission)
- Nutritional state(During ICU-admission)