Insight in the Development and Recovery of Hypernatremia in Critically Ill Patients.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypernatremia
- Sponsor
- Catharina Ziekenhuis Eindhoven
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Development of hypernatremia
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. Previous studies focused on predictors in the development and recovery of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and salt balance or renal replacement therapy is lacking. This study aims to provide better insight in the development and recovery of hypernatremia through the collection of detailed information on the input and output of fluids and salts in a larger group of patients than studied before.
Detailed Description
Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. The main mechanism is an imbalance between sodium and total body water. Consequently, this poses multiple factors to play a role in the development of hypernatremia. multifactorial. Previous studies focused on predictors in the development of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and salt balance or renal replacement therapy is lacking. Few studies investigated the recovery of hypernatremia, which showed that correction of hypernatremia can reduce the associated mortality risk. This study aims to provide better insight in the development and recovery of hypernatremia through the collection of detailed information on the input and output of fluids and salts in a larger group of patients than studied before.
Investigators
Eveline Mestrom
Doctor of Medicine, Principal Investigator
Catharina Ziekenhuis Eindhoven
Eligibility Criteria
Inclusion Criteria
- •Adults \>17 years old
- •Admitted \>48 hours in ICU
Exclusion Criteria
- •Expected discharge same day as day of inclusion
Outcomes
Primary Outcomes
Development of hypernatremia
Time Frame: During ICU admission
Serum sodium levels \>145mmol/L
Recovery of hypernatremia
Time Frame: During ICU admission
Serum sodium levels returning back to levels below 146mmol/L
Secondary Outcomes
- Mortality(During ICU admission as well as during hospital admission)
- Length of stay(Admission in ICU as well as in hospital)