Prospective Data Analysis of the Development of Hypernatremia in Intensive Care Unit

Completed

• Conditions: Hypernatremia

• Registration Number: NCT03752450
• Lead Sponsor: Catharina Ziekenhuis Eindhoven

Brief Summary

Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. Previous studies focused on predictors in the development and recovery of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and salt balance or renal replacement therapy is lacking. This study aims to provide better insight in the development and recovery of hypernatremia through the collection of detailed information on the input and output of fluids and salts in a larger group of patients than studied before.

Detailed Description

Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. The main mechanism is an imbalance between sodium and total body water. Consequently, this poses multiple factors to play a role in the development of hypernatremia. multifactorial. Previous studies focused on predictors in the development of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and salt balance or renal replacement therapy is lacking. Few studies investigated the recovery of hypernatremia, which showed that correction of hypernatremia can reduce the associated mortality risk.

This study aims to provide better insight in the development and recovery of hypernatremia through the collection of detailed information on the input and output of fluids and salts in a larger group of patients than studied before.

Study Timeline

• Study Start: 2018-05-25
• Study First Submitted: 2018-11-21
• Study First Submitted QC: 2018-11-21
• Study First Posted: 2018-11-26
• Primary Completion: 2018-12-20
• Status Verified: 2019-04
• Study Completion: 2019-04-10
• Last Update Submitted: 2019-04-10
• Last Update Posted: 2019-04-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Adults >17 years old
• Admitted >48 hours in ICU

Exclusion Criteria

• Expected discharge same day as day of inclusion

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Development of hypernatremia	During ICU admission	Serum sodium levels \>145mmol/L
Recovery of hypernatremia	During ICU admission	Serum sodium levels returning back to levels below 146mmol/L

Secondary Outcome Measures

Name	Time	Method
Mortality	During ICU admission as well as during hospital admission	Patient did or did not pass away.
Length of stay	Admission in ICU as well as in hospital	Number of days of admission

Trial Locations

Locations (1)

Catharina Hospital Eindhoven; 🇳🇱 Eindhoven, Noord-Brabant, Netherlands