Development of Hypernatremia in Critically Ill Patients: Prospective Analysis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypernatremia
- Sponsor
- Catharina Ziekenhuis Eindhoven
- Enrollment
- 1500
- Locations
- 1
- Primary Endpoint
- Hypernatremia
- Last Updated
- 4 years ago
Overview
Brief Summary
Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. Previous studies focused on predictors in the development and recovery of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and sodium balance or renal replacement therapy is lacking. The predecessor of this study was the HYPNIC trial which found that increased sodium load en decreased sodium excretion preceded hypernatremia development, but was lacking information on the first 48 hours, fluid balances were manually collected before a new data collection system was introduced and was suffering from substantial amounts of missing data and small population for trend analysis.
This study aims to provide better insight in the development and recovery of hypernatremia while paying attention to the limitations from the HYPNIC trial.
Investigators
Eveline Mestrom
Principal Investigator
Catharina Ziekenhuis Eindhoven
Eligibility Criteria
Inclusion Criteria
- •Admitted to Intensive Care Unit
- •Age 18 years or older
Exclusion Criteria
- •Age 17 years or younger
Outcomes
Primary Outcomes
Hypernatremia
Time Frame: During admission in ICU
After one year of collecting data on fluid and sodium balances, the patients who developed hypernatremia during their admission in the Intensive Care Unit will be compared to the patients who remained normonatremic throughout their ICU admission.
Secondary Outcomes
- 24 hour urine replacement for spot-checks(24 hours)