NCT01974739CompletedNot Applicable
Hypernatraemia and Diuretics in Intensive Care Patients
Medical Centre Leeuwarden1 site in 1 country50 target enrollmentStarted: September 2013Last updated:
Conditions
Interventions
Drugs
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- sodium level
Study Overview
Brief Summary
Acquired hypernatremia appears to be associated with mortallity in ICU. To reduce hypernatremia and shorten the time of hypernatremia, we investigate the effect of hydrochloorthiazide compared to a placebo
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •sodium > 142
Exclusion Criteria
- •no informed consent
Arms & Interventions
hydrochloorthiazide
Active Comparator
once a day 25 mg
Intervention: Hydrochloorthiazide (Drug)
placebo
Placebo Comparator
once a day placebo
Intervention: placebo (Drug)
Outcomes
Primary Outcomes
sodium level
Time Frame: 7 days
a decrease of 5 mmol/L sodium in plama
Secondary Outcomes
- time hypernatraemia(7 days)
Investigators
E.C. Boerma
MD PhD
Medical Centre Leeuwarden
Study Sites (1)
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