NCT00291863Unknown4 期
Simvastatin Effect on Endothelium Dependent Venodilation in Chronic Renal Failure Patients Treated by Peritoneal Dialysis
Federal University of São Paulo1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2006年2月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- endothelial venodilation
研究概览
简要总结
This study will analyse the effect of simvastatin on endothelium dependent venodilation in chronic renal failure patients treated by peritoneal dialysis. The hypothesis is that patients will have a greater endothelium dependent venodilation after four months of simvastatin use.
详细描述
This study will analyse the effect of simvastatin on endothelium dependent venodilation in chronic renal failure patients treated by peritoneal dialysis. The hypothesis is that patients will have a greater endothelium dependent venodilation after four months of simvastatin use.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •end stage renal failure
- •peritoneal dialysis
- •LDL cholesterol > 100mg/dL
- •> 18 years and < 80 years
排除标准
- •using statin or nitrate
- •liver disease
- •diabetes mellitus
结局指标
主要结局
endothelial venodilation
次要结局
- Inflammation markers (C-reactive protein, IL-6, TNF)
- Lipoproteins
- Oxidative stress
研究者
研究点 (1)
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