Vitamins ,Minerals and Amino Acids Supplement Intake in Infertile Men;the Effect on Sperm Parameters,Fertilization Rate and Embryo Quality. A Double Blind Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Sperm parameters
研究概览
简要总结
The vitamin,minerals and amino acid supplementation for 3 months will improve the semen parameters,fertilization rate and embryo quality in subfertile men undergoing IVF treatment
详细描述
With the supplement intake containing amino acids, vitamins and minerals designed to improve sperm parameters, the couples undergoing IVF treatment will benefit as the change and improvement of sperm parameters will increase the fertilization rate and improve the embryo quality thus allowing shorter time for pregnancy achievement and less frustration with long duration of treatments
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy male age 20-50
- •at least one IVF cycle without pregnancy
- •sperm parameters:
- •Oligospermia 5-20*106
- •Teratospermia 6-14% normal forms
- •Asthenospermia <30% motility
排除标准
- •female factor infertility
- •age > 50 or under 20
- •testicular problem on physical examination
- •history of malignancy and /or chemotherapy
- •usage of antiandrogen/testosterone
- •history of drug abuse/alcohol
- •a known endocrinological problem
- •current STD or genitourinary infection
- •Retrograde Ejaculation
- •Y chromosome microdeletion
- •Karyotype abnormalities
结局指标
主要结局
Sperm parameters
时间窗: 3 months of treatment
Men suffering from a "male factor" problem and after one failed IVF treatment will be given the supplement for 3 months after which the sperm parametrs will be evaluated and compared to pre-supplement data and later the embryo quality and fertilization rate will reviewed analyzed and compared
次要结局
未报告次要终点