Association Between 4D MRI Parameters and the Clinical Characteristics and Prognosis of Major Chronic Diseases
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Association between 4D flow MRI-derived hemodynamic parameters and disease-specific clinical outcomes
研究概览
简要总结
Cancer and cardiovascular diseases are among the leading causes of morbidity and mortality worldwide. Advanced imaging techniques such as 4D magnetic resonance imaging (MRI) enable quantitative assessment of hemodynamic and functional parameters beyond conventional imaging. The aim of this study is to evaluate the association between 4D MRI derived parameters and the occurrence, severity, and prognosis of major chronic diseases, and to explore their potential role as imaging biomarkers.
详细描述
This is a single-center, prospective, observational registry study conducted at Ulsan University Hospital. The study will enroll 1,000 adult patients (≥ 19 years) undergoing cardiac MRI as part of routine clinical care in Korea.
Participants will undergo an additional 4D MRI sequence during the same imaging session, which does not affect clinical decision-making or patient management.
The primary objective of this study is to evaluate the association between quantitative imaging parameters derived from 4D MRI and the occurrence, severity, and prognosis of major chronic diseases.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults aged 19 years and older undergoing clinically indicated Cardiac MRI at Ulsan University Hospital
- •Participants who undergo an additional 4D MRI sequence during the same imaging session
- •Participants who are able to understand the study and provide written informed consent
排除标准
- •Individuals aged < 19 years
- •Individuals with cognitive impairment or communication difficulties unable to provide informed consent
- •Poor-quality MRI images that are not suitable for analysis
- •Individuals deemed inappropriate for study participation by the investigator
研究组 & 干预措施
Ulsan University Hospital, 4D MRI cohort
Adult patients aged 19 years and older undergoing clinically indicated Cardiac MRI at Ulsan University Hospital who provide written informed consent and undergo an additional 4D MRI sequence during the same imaging session.
结局指标
主要结局
Association between 4D flow MRI-derived hemodynamic parameters and disease-specific clinical outcomes
时间窗: up to 10 years
The association between quantitative hemodynamic parameters derived from 4D flow MRI and pre-specified disease-specific clinical outcomes will be evaluated during follow-up.
Incidence of Major Adverse Cardiovascular Events (MACE)
时间窗: up to 10 years
Incidence of major adverse cardiovascular events, including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure during the follow-up period
次要结局
- Peak Wall Shear Stress(Perioperative/Periprocedural)
- Blood Flow Eccentricity(Perioperative/Periprocedural)
研究者
Gyung-Min Park
MD, PhD
Ulsan University Hospital