A Phase I Study of Intensity-modulated Radiotherapy in Patients With Squamous Cell Carcinoma of Unknown Primary (SCCUP) of the Head and Neck
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 主要终点
- Feasibility of delivering IMRT
研究概览
简要总结
Squamous cell carcinoma of unknown primary (SCCUP) site metastatic to cervical lymph nodes at presentation is a relatively rare entity forming about 2% of all head and neck carcinomas.
Typically patients are treated with ipsilateral modified radical neck dissection (MRND) and post-operative radiotherapy (PORT) or chemoradiotherapy.
There is a lack of consensus on the radiotherapy target volumes that should be treated after neck dissection. The most common radiotherapy techniques are either unilateral cervical lymph node irradiation to achieve local control in the ipsilateral neck or TMI of the head and neck region with the aim of eradicating the primary and the microscopic neck disease.
Treatment of the ipsilateral hemi-neck alone is of low toxicity and may achieve local control in the cervical nodes. Potential occult primary sites in the head and neck mucosa, and any sub-clinical metastatic disease in the contralateral side of the neck are left untreated. If a primary tumour subsequently becomes apparent the previous radiotherapy may make further radiotherapy difficult to deliver.
Some groups recommend bilateral neck and total mucosal irradiation in this setting claiming improved local control. With conventional radiotherapy technique this is at the price of significant acute toxicity and chronic morbidity, mainly xerostomia with its associated complications and effects on quality of life (QOL).
Intensity modulated radiotherapy (IMRT) has been shown to reduce the dose to salivary gland tissue and consequently may reduce the incidence of xerostomia and improve quality of life (QOL) in head and neck cancer patients.
An analysis of parotid-sparing IMRT at the University of Michigan established a mean dose threshold for both stimulated (26 Gy), and unstimulated (24 Gy) saliva flow rates. For the same end-point (less than 25% of flow at baseline one year post radiation) Roesink et al established a TD50 of 39 Gy.
The investigators performed a planning study to assess the feasibility of IMRT to spare the parotid gland while delivering bilateral neck and TMI. The mean dose to the contralateral parotid gland using IMRT was below the threshold of 24 Gy for unstimulated salivary flow, predicting a fairly low risk of radiation induced xerostomia. The mean dose to the ipsilateral parotid gland was 32 Gy which was below the TD50 dose based on the Roesink data.
This study assesses the safety and tolerability of delivering IMRT in clinical practice to treat patients with SCCUP of the head and neck region, who require bilateral neck and pan-mucosal irradiation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Squamous cell carcinomas metastatic to cervical lymph node with occult primary requiring bilateral neck and pan mucosal irradiation.
- •Radiotherapy either as primary therapy or post-operative (adjuvant irradiation).
- •Neoadjuvant and concomitant chemotherapy are permitted.
- •All patients must be suitable to attend regular follow-up and undergo toxicity assessment.
- •Stage T0, N1-3, M0 disease
- •WHO Performance Status 0-
- •Patient should have a negative PET/CT scan for a primary tumour.
排除标准
- •Previous radiotherapy to the head and neck region
- •Previous malignancy except non-melanoma skin cancer
- •Previous or concurrent illness which in the investigators opinion would interfere with either completion of therapy or follow-up
- •Prophylactic use of amifostine or pilocarpine is not allowed
- •Brachytherapy is not allowed as part of the treatment
结局指标
主要结局
Feasibility of delivering IMRT
时间窗: 7 weeks after starting radiotherapy
Feasibility of delivering IMRT in this setting i.e. all the patients completing the radiotherapy protocol without treatment breaks due to toxicity.
次要结局
- Incidence of acute dermatitis(3 months after RT)
- Incidence of >grade 1 late xerostomia(5 years)
- Number of patients who do not relapse at the local site(5 years)
- Overall survival(5 years)
- Incidence of acute alopecia(3 months after RT)
- Incidence of >grade 1 acute dysphagia(3 months after RT)
- Incidence of > grade 1 acute mucositis(3 months after RT)
- Incidence of acute radiation induced pain(3 months after RT)
- Incidence of >grade 1 acute xerostomia(3 months after RT)
- Incidence of acute radiation induced fatigue(3 months after RT)
- Incidence of > grade 1 late dysphagia(5 years after RT)
- Incidence of late oesophageal stricture(5 years after RT)
- Incidence of >grade 1 late hoarse voice(5 years after RT)
- Incidence of late radiation induced neurological dysfunction(5 years)
- Incidence of >grade1 late skin toxicity(5 years after RT)