Health Qigong Alleviates Depressive Symptoms in Older Adults Through Enhanced Executive Attention: a Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 200
- 主要终点
- Executive attention
研究概览
简要总结
The goal of this randomized controlled trial is to test whether executive attention unpacks the antidepressant effect of Baduanjin (a form of health qigong) in older adults.
The main questions it aims to answer are:
- Is Baduanjin an effective treatment to enhance executive attention in older adults with depressive symptoms?
- Does Baduanjin work through enhanced executive attention to alleviate depressive symptoms in older adults? Researchers will compare Baduanjin with waitlist control. Participants will receive 12-week Baduanjin training (two sessions per week and 60 min per session).
详细描述
Baduanjin is a type of health qigong that has been shown to effectively reduce depressive symptoms in older adults. However, the cognitive mechanism that explains such antidepressant effect remains unclear. Executive attention represents the cognitive processing that deals with interference and conflict, and it is likely to be a mechanism to unpack Baduanjin's treatment effect on depressive symptoms. There is also a lack of understanding of Badunajin's effects on brain activation in depressed older adults. To address these knowledge gaps, we propose a fully powered randomized controlled trial (RCT) with 198 older adults with at least mild depressive symptoms. They will be randomly assigned to either the active intervention group (12-week Baduanjin training) or the waitlist control group. The primary outcome is executive attention. Secondary outcomes include depressive symptoms, amplitudes of N2 and P3 components (i.e., components of event-related potentials in brain) during attention tasks, and alerting and orienting networks of attention. These outcomes will be assessed at baseline and post-intervention (12 weeks after baseline). Repeated measures ANOVA will be used to test for treatment effects on the primary outcome. Executive attention's mediation effect on the linkage between group (intervention vs waitlist control) and depressive symptoms will be tested with SPSS Macro PROCESS. The Baduanjin-related enhancement in N2 amplitude, P3 amplitude, alerting, and orienting will be explored with repeated measures ANOVA, respectively. Correlation analyses will be used to evaluate the association (i) between changes in N2 and P3 amplitudes and changes in executive attention and (ii) between changes in N2 and P3 amplitudes and changes in depressive symptoms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •have mild or severer levels of depressive symptoms, as indicated by Geriatric Depression Scale scores of 5 or above or Depression Anxiety and Stress Scale-21 depression subscale scores of 4 or above
- •self-identified as physically stable and without life-threatening diseases
- •be able to communicate in Cantonese or Mandarin.
排除标准
- •(have a history of practicing or receiving training in any form of mind-body or regular exercises (including tai chi, yoga, and qigong or regular physical activity > 3 times/week) during the month prior to recruitment
- •have changed medications or the dose of medications prescribed for their health condition in the month prior to study enrollment
- •have a severe cognitive or language impairment, as indicated by a score of less than 21 on the Montreal Cognitive Assessment
- •receiving pharmacological treatment, electroconvulsive therapy, psychotherapy, or psychoeducation for any psychological or psychiatric condition upon the time of recruitment
- •be unable to demonstrate satisfactory standing balance.
研究组 & 干预措施
Baduanjin
This arm is for intervention group who will receive health qigong training.
干预措施: Health qigong training (Behavioral)
Waitlist control
The arm is for control group who will not receive any training.
结局指标
主要结局
Executive attention
时间窗: Baseline and post-intervention (12 weeks after baseline)
The Attention Network Test (ANT) will be used to assess executive attention. The ANT is a computer-based test based on a combination of Posner's cueing task and the Flanker task. Executive attention will be operationalized as the difference in reaction time (measured in ms) in congruent and incongruent trials.
次要结局
- Amplitude of N2 component(Baseline and post-intervention (12 weeks after baseline))
- Depressive symptoms(Baseline and post-intervention (12 weeks after baseline))
- Amplitude of P3 component(Baseline and post-intervention (12 weeks after baseline))
- Alerting(Baseline and post-intervention (12 weeks after baseline))
- Orienting(Baseline and post-intervention (12 weeks after baseline))
研究者
LU Yiqing Erin
Research Assistant Professor
The Hong Kong Polytechnic University