Acute Effects of Intermittent Inspiratory Muscle Training on Blood Glucose and Vascular Function Responses
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 48
- 主要终点
- Blood glycaemic responses
研究概览
简要总结
The purpose of this study is to investigate whether inspiratory muscle training has an immediate effect on energy expenditure, heart rate, blood glucose, blood pressure, and arterial stiffness in healthy adults, obese adults, and adults with type 2 diabetes.
详细描述
Participants will be asked to complete two trials involving intermittent exercise, which will include eupnea and inspiratory muscle training (IMT), as well as a resting control condition, in a randomized crossover study design. The trials will be separated by a minimum of 48 hours and will be completed within a 7-day period. Throughout all trials, participants will be required to remain relaxed and seated on an adjustable examination bed. For the IMT intensity, participants will utilize an inspiratory muscle training device (PowerBreathe Plus, Powerbreathe International Ltd., UK) and adjust the resistance to a level at which breathing continuously for 20 breaths is perceived as "somewhat hard" (RPE = 13), according to the Rating of Perceived Exertion (RPE) scale. This will take place during a 3.5-hour oral glucose tolerance test (OGTT). During the trials, participants may watch television or read; however, typing on a laptop or computer will be prohibited.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults, obese adults and adults with type 2 diabetes
- •Aged between 20 to 45 years
- •Weight stable for more than 3 months (no change in weight +/- 3%)
- •Non-smoker
- •Non-highly trained athletic team members
- •Normal lifestyle patterns
排除标准
- •Personal history of/existing hypertension, respiratory infectious disease, cardiovascular disease, metabolic disease
- •Taking medications that may influence lipid or carbohydrate metabolism or immune system function
研究组 & 干预措施
Eupnea
Participants will breathe normally.
干预措施: Eupnea (Behavioral)
Inspiratory muscle training
Intermittent inspiratory muscle training (IMT) will be conducted throughout the trial
干预措施: Intermittent inspiratory muscle training (IIMT) (Behavioral)
结局指标
主要结局
Blood glycaemic responses
时间窗: 0 (baseline), 30, 60, 120, and 210 minutes during the 210-minute trial
Changes in blood glycaemic responses between trials
Pulse wave velocity (PWV)
时间窗: 0 (baseline), 30, 60, 90, 150, and 210 minutes during the 210-minute trial
Changes in pulse wave velocity between trials
次要结局
- Energy expenditure(First 90 minutes during the 210-minute trial)
- Heart Rate Variability (HRV)(In a regular patterns during the 210-minute trial)
- Visual analogue scale (VAS)(Every 30 minutes during the 210-minute trial)
- Perceived stress scale (PSS)(Every 30 minutes during the 210-minute trial)
研究者
Yung-Chih Chen
Principal Investigator
National Taiwan Normal University