Sinonasal Gas Exchange Dynamics The Aerodynamic Theory of the Sinonasal Interface
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Sinonasal gas exchange rate
研究概览
简要总结
Sinonasal gas exchange is facilitated by the unique anatomy and topography of the sinonasal interface that represents a collection of airfoils creating an aerodynamic structure. The airflow during respiration generates positive and negative pressures that power the gas exchange between the sinuses and the nose. Major surgical alteration of the interface reduces the rate and velocity of the exchange. Minimally invasive procedures aimed at preserving the natural anatomy, topography and aerodynamic configuration of the interface will have negligible effects on sinonasal gas exchange.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •normal healthy adult volunteers ages 18-65,
- •without allergies by history and allergy test,
- •non-smoker,
- •not using steroids. Study group 1: adult subjects who had maxillary sinus balloon sinuplasty (with intact uncinate and ethmoid complex) Study group 2: adult subjects who had endoscopic maxillary antrostomy and uncinectomy.
- •Exclusion criteria:
- •active acute or chronic infection,
- •nasal polyps,
- •severe nasal or septal deformity,
- •cystic fibrosis,
- •systemic illness (diabetes, hypertension etc.),
- •vulnerable population (children, pregnant women, institutionalized individuals etc.)
- •severe nasal and/or septal deviation,
- •hypersensitivity or intolerance to study medications (topical and local anesthetics) any turbinate surgery.
排除标准
- 未提供
结局指标
主要结局
Sinonasal gas exchange rate
时间窗: 2 years
ANALYZE AND DEFINE GAS EXCHANGE PATTERNS IN THE MAXILLARY SINUS DURING NASAL RESPIRATION IN NORMAL SINUSES AND COMPARE WITH SURGICALLY MODIFIED SUBJECTS THAT WILL INCLUDE MAXILLARY SINUSES AFTER ENDOSCOPIC SINUS SURGERY AND BALLOON SINUPLASTY.
次要结局
- NO production rate(2 years)
研究者
Anil Gungor MD
Associate Professor
Louisiana State University Health Sciences Center Shreveport