NCT02074124已完成不适用
Abdominal Tissue Perfusion Changes in Esophageal and Gastric Cancer During Adenosine Vasodilation Measured With Computed Tomography (CT) Perfusion
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Change in arterial flow during adenosine vasodilation test (CT perfusion parameter)
研究概览
简要总结
The aim of this study was to investigate changes in abdominal tissue perfusion during adenosine vasodilation. Our hypotheses were that CT perfusion measurements are altered by changes in the circulatory system mediated by adenosine, and a more differentiated assessment of the circulatory capacity of abdominal tumours could be achieved by sequential rest and adenosine vasodilation CT perfusion measurements.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Tumour larger than 1.5 cm on diagnostic CT
- •Normal serum creatinine
- •Age above 18
- •Informed written and oral consent.
排除标准
- •Contrast allergy or contrast induced nephropathy
- •BMI > 40
- •Asthma or Chronic Obstructive Lung Disease
- •Heart failure (NYHA III+)
- •Heart conduction disorder
- •Atrial fibrillation
- •2nd/3rd Heart block
- •Long QT syndrome
- •Wolf Parkinson White Syndrome
- •Moderate / severe aortic stenosis
- •Haemodynamic contraindications for adenosine, systolic pressure below 90
结局指标
主要结局
Change in arterial flow during adenosine vasodilation test (CT perfusion parameter)
时间窗: 0 min and 15 min
次要结局
- Change in Blood pressure during adenosine vasodilation test(0 min and 15 min)
- Change in Heart rate during adenosine vasodilation test(0 min and 15 min)
- Change in Area under arterial input curve during adenosine vasodilation test(0 min and 15 min)
- Change in Blood volume (CT perfusion parameter) during adenosine vasodilation test(0 min and 15 min)
- Change in Permeability (CT perfusion parameter) during adenosine vasodilation test.(0 min and 15 min)
研究者
Martin Lundsgaard Hansen
MD
Rigshospitalet, Denmark
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Esophageal epithelial permeability changes in patients with allergic esophagitis.Eosinophilic esophagitis, pathophysiology, etiology, epithelial barrier integrity, permeability.Eosinofiele oesofagitis, pathofysiologie, etiologie, epitheliale barrierefunctie, permeabiliteit.NL-OMON28827Academic Medical Center, Amsterdam, The Netherlands16
未知
不适用
Evaluation of tissue blood flow for the digestive tract and the liver by finger-mounted tissue oximetry during peri-oerative period in patients undergoing gastroenterological and hepatobiliary surgeryPtients who are going to undergo gastrointestinal (GI) surgery (for GI tract malignancies, inflammatory bowel disease, or bowel obstruction) or hepatectomy (for hepatobiliary malignancies)JPRN-UMIN000026663Second Department of Surgery, Hamamatsu University School of Medicine400
尚未招募
不适用
MR Adenosine Perfusion in the functional evaluation of patients undergoing PCI for single or two vessel diseaseNL-OMON29951niversitair Medisch Centrum Groningen15
已完成
不适用
A trial on the influence of esophageal acidification on sleep bruxismSleep BruxismJPRN-UMIN000004499Department of Orthodontics, Kagoshima University Graduate School of Medical and Dental Sciences12
已完成
3 期
Adipose Secretory Function in Patients Before & After Laparoscopic SurgeryObesityNCT00495599Vanderbilt University107