Esophageal epithelial permeability changes in patients with allergic esophagitis.

Recruiting

• Conditions: Eosinophilic esophagitis, pathophysiology, etiology, epithelial barrier integrity, permeability.Eosinofiele oesofagitis, pathofysiologie, etiologie, epitheliale barrierefunctie, permeabiliteit.

• Registration Number: NL-OMON28827
• Lead Sponsor: Academic Medical Center, Amsterdam, The Netherlands

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

Eosinophilic esophagitis group:

1. Previous diagnosis of EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in mid-esophageal biopsies before the start of any therapy;

Exclusion Criteria

Eosinophilic esophagitis group:

1. Inability to stop topical corticosteroids;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Size of esophageal epithelial intercellular spaces in EoE patients and healthy controls;<br /><br>2. Permeability of esophageal mucosa to small molecules in EoE patients and healthy controls;<br /><br>3. Tissue impedance of esophageal epithelium (in vivo) in EoE patients and healthy controls;<br /><br>4. Numbers of esophageal intraepithelial mast cells and eosinophils in EoE patients and healthy controls.

Secondary Outcome Measures

Name	Time	Method
Reversibility of abovementioned (permeability) changes by proton pump inhibition in EoE patients.