Characterisation of esophageal epithelial damage in patients with non-erosive reflux disease (NERD) and erosive esophagitis (EE): role of epithelial permeability - Epithelial damage in GERD

Medisch Universitair Ziekenhuis Maastricht0 sites35 target enrollmentTBD

Overview

No summary available.

Registry

who.int

Start Date

TBD

End Date

September 15, 2014

Last Updated

2 years ago

Study Type

Observational invasive

Sponsor

Medisch Universitair Ziekenhuis Maastricht

•GERD PATIENTS
•Inclusie criteria:
•Patients with typical GERD\-symptoms lasting for more than 6 months (recurrent episodes of heartburn or acid regurgitation) and abnormal pH\-parameters (pathological acid exposure and/or symptom association) or a positive response to PPI\-therapy will be included. ;HEALTHY VOLUNTEERS
•Inclusion criterium: No history of gastrointestinal disease, especially gastroesophageal reflux.

•GERD PATIENTS
•Exclusion\-criteria:
•1\) Age \<18 years
•2\) Previous esophageal or gastric surgery
•3\) Severe esophageal motility disorder on manometry
•4\) Histological evidence of Barrett\*s mucosa
•5\) Severe co\-morbidities (including cardiopulmonary disease, portal hypertension,collagen diseases, morbid obesity, coagulation disorders and co\-morbidity hindering a gastroscopic procedure)
•6\) Use of anticoagulant or immunosuppressive drugs
•7\) Inability to stop medication that can influence the test results, like PPI, for at least 1 week before tests
•8\) Patients unable to give informed consent.