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Clinical Trials/NL-OMON37810
NL-OMON37810
Completed
Not Applicable

Characterisation of esophageal epithelial damage in patients with non-erosive reflux disease (NERD) and erosive esophagitis (EE): role of epithelial permeability - Epithelial damage in GERD

Medisch Universitair Ziekenhuis Maastricht0 sites35 target enrollmentTBD

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
GERD
Sponsor
Medisch Universitair Ziekenhuis Maastricht
Enrollment
35
Status
Completed
Last Updated
2 years ago

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
September 15, 2014
Last Updated
2 years ago
Study Type
Observational invasive

Investigators

Sponsor
Medisch Universitair Ziekenhuis Maastricht

Eligibility Criteria

Inclusion Criteria

  • GERD PATIENTS
  • Inclusie criteria:
  • Patients with typical GERD\-symptoms lasting for more than 6 months (recurrent episodes of heartburn or acid regurgitation) and abnormal pH\-parameters (pathological acid exposure and/or symptom association) or a positive response to PPI\-therapy will be included. ;HEALTHY VOLUNTEERS
  • Inclusion criterium: No history of gastrointestinal disease, especially gastroesophageal reflux.

Exclusion Criteria

  • GERD PATIENTS
  • Exclusion\-criteria:
  • 1\) Age \<18 years
  • 2\) Previous esophageal or gastric surgery
  • 3\) Severe esophageal motility disorder on manometry
  • 4\) Histological evidence of Barrett\*s mucosa
  • 5\) Severe co\-morbidities (including cardiopulmonary disease, portal hypertension,collagen diseases, morbid obesity, coagulation disorders and co\-morbidity hindering a gastroscopic procedure)
  • 6\) Use of anticoagulant or immunosuppressive drugs
  • 7\) Inability to stop medication that can influence the test results, like PPI, for at least 1 week before tests
  • 8\) Patients unable to give informed consent.

Outcomes

Primary Outcomes

Not specified

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