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临床试验/NL-OMON37810
NL-OMON37810
已完成
不适用

Characterisation of esophageal epithelial damage in patients with non-erosive reflux disease (NERD) and erosive esophagitis (EE): role of epithelial permeability - Epithelial damage in GERD

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 35 人待定

概览

阶段
不适用
干预措施
未指定
疾病 / 适应症
GERD
发起方
Medisch Universitair Ziekenhuis Maastricht
入组人数
35
状态
已完成
最后更新
2年前

概览

简要总结

暂无简介。

注册库
who.int
开始日期
待定
结束日期
2014年9月15日
最后更新
2年前
研究类型
Observational invasive

研究者

发起方
Medisch Universitair Ziekenhuis Maastricht

入排标准

入选标准

  • GERD PATIENTS
  • Inclusie criteria:
  • Patients with typical GERD\-symptoms lasting for more than 6 months (recurrent episodes of heartburn or acid regurgitation) and abnormal pH\-parameters (pathological acid exposure and/or symptom association) or a positive response to PPI\-therapy will be included. ;HEALTHY VOLUNTEERS
  • Inclusion criterium: No history of gastrointestinal disease, especially gastroesophageal reflux.

排除标准

  • GERD PATIENTS
  • Exclusion\-criteria:
  • 1\) Age \<18 years
  • 2\) Previous esophageal or gastric surgery
  • 3\) Severe esophageal motility disorder on manometry
  • 4\) Histological evidence of Barrett\*s mucosa
  • 5\) Severe co\-morbidities (including cardiopulmonary disease, portal hypertension,collagen diseases, morbid obesity, coagulation disorders and co\-morbidity hindering a gastroscopic procedure)
  • 6\) Use of anticoagulant or immunosuppressive drugs
  • 7\) Inability to stop medication that can influence the test results, like PPI, for at least 1 week before tests
  • 8\) Patients unable to give informed consent.

结局指标

主要结局

未指定

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