Characterisation of esophageal epithelial damage in patients with non-erosive reflux disease (NERD) and erosive esophagitis (EE): role of epithelial permeability - Epithelial damage in GERD

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 35 人开始时间: 待定最近更新: 2024年4月29日

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•GERD PATIENTS
•Inclusie criteria:
•Patients with typical GERD-symptoms lasting for more than 6 months (recurrent episodes of heartburn or acid regurgitation) and abnormal pH-parameters (pathological acid exposure and/or symptom association) or a positive response to PPI-therapy will be included. ;HEALTHY VOLUNTEERS
•Inclusion criterium: No history of gastrointestinal disease, especially gastroesophageal reflux.

•GERD PATIENTS
•Exclusion-criteria:
•1) Age <18 years
•2) Previous esophageal or gastric surgery
•3) Severe esophageal motility disorder on manometry
•4) Histological evidence of Barrett*s mucosa
•5) Severe co-morbidities (including cardiopulmonary disease, portal hypertension,collagen diseases, morbid obesity, coagulation disorders and co-morbidity hindering a gastroscopic procedure)
•6) Use of anticoagulant or immunosuppressive drugs
•7) Inability to stop medication that can influence the test results, like PPI, for at least 1 week before tests
•8) Patients unable to give informed consent.
•9) Excessive alcohol consumption (>20 units per week);HEALTHY VOLUNTEERS
•Exclusion-criteria:
•1) Age <18 years
•2) Co-morbidities (including cardiopulmonary disease, collagen diseases, obesity, coagulation disorders and co-morbidity hindering a gastroscopic procedure)
•3) Inability to stop medication that can influence the test results, like PPI, for at least 1 week before tests
•4) Subjects unable to give informed consent.
•5) Excessive alcohol consumption (>20 units per week)

发起方

Medisch Universitair Ziekenhuis Maastricht