NL-OMON37810
已完成
不适用
Characterisation of esophageal epithelial damage in patients with non-erosive reflux disease (NERD) and erosive esophagitis (EE): role of epithelial permeability - Epithelial damage in GERD
Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 35 人待定
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- GERD
- 发起方
- Medisch Universitair Ziekenhuis Maastricht
- 入组人数
- 35
- 状态
- 已完成
- 最后更新
- 2年前
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •GERD PATIENTS
- •Inclusie criteria:
- •Patients with typical GERD\-symptoms lasting for more than 6 months (recurrent episodes of heartburn or acid regurgitation) and abnormal pH\-parameters (pathological acid exposure and/or symptom association) or a positive response to PPI\-therapy will be included. ;HEALTHY VOLUNTEERS
- •Inclusion criterium: No history of gastrointestinal disease, especially gastroesophageal reflux.
排除标准
- •GERD PATIENTS
- •Exclusion\-criteria:
- •1\) Age \<18 years
- •2\) Previous esophageal or gastric surgery
- •3\) Severe esophageal motility disorder on manometry
- •4\) Histological evidence of Barrett\*s mucosa
- •5\) Severe co\-morbidities (including cardiopulmonary disease, portal hypertension,collagen diseases, morbid obesity, coagulation disorders and co\-morbidity hindering a gastroscopic procedure)
- •6\) Use of anticoagulant or immunosuppressive drugs
- •7\) Inability to stop medication that can influence the test results, like PPI, for at least 1 week before tests
- •8\) Patients unable to give informed consent.
结局指标
主要结局
未指定
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