The Relationship Between Normal Saline Infusion and Acute Kidney Injury in Patients With Heat Stroke
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 104
- 试验地点
- 9
- 主要终点
- Acute kidney injury
研究概览
简要总结
The goal of this clinical trial is to compare the effect of high chlorine solution such as normal saline and non-high chlorine solution such as sodium lactate ringer's solution on renal function in patients with heat stroke. The main question it aims to answer is whether limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke.
Participants will receive a free normal saline infusion during the emergency department according to the study design, or a restricted normal saline infusion while using sodium lactate Ringer's instead.
Researchers will compare the normal saline infusion group and sodium lactate Ringer's group to see if limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥ 18 years
- •diagnosed as heat stroke
- •Informed consent from patients or family members.
排除标准
- •need immediate cardiopulmonary resuscitation
- •transferred from another hospital
- •with original end-stage renal disease or dialysis
- •with severe organ damage
- •pregnant women
研究组 & 干预措施
Normal Saline infusion group
During the emergency department, the normal saline infusion was not restricted.
干预措施: Normal Saline infusion and Ringer lactate infusion (Drug)
Ringer lactate infusion group
Use ringer lactate or other balanced crystallographic solution instead of normal saline. Strictly limit the amount of normal saline infusion. Normal saline will only be infused by medical advice if the patient has hypochloremia or needs saline as solvent.
干预措施: Normal Saline infusion and Ringer lactate infusion (Drug)
结局指标
主要结局
Acute kidney injury
时间窗: up to 90 days
Acute kidney injury was defined as increase in serum creatinine by 50% within 7 days, or increase in serum creatinine by 0.3 mg/dl (26.5μmol/l) within 2 days, or oliguria
次要结局
- in-hospital mortality(up to 90 days)
- Continuous renal replacement therapy(up to 90 days)
- length of ICU stay(up to 90 days)